Melphalan


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult: PO Multiple myeloma 150 mcg/kg/day in divided doses for 4-7 days, followed by rest period (for haematologic recovery) up to 6 wk, then repeat the course or start maintenance w/ 1-3 mg/day. Breast cancer 150 mcg/kg/day, repeat 6 wkly. Ovarian carcinoma 200 mcg/kg/day for 5 days 4-8 wkly. Polycythaemia vera 6-10 mg/day for 5-7 days; 2-4 mg/day for remission induction. Maintenance: 2-6 mg/wk. IV Ovarian adenocarcinoma 1 mg/kg as a single dose, repeat in 4 wk if platelet and neutrophil counts permit. Multiple myeloma 400 mcg/kg /m2 via infusion, 1st 4 doses may be given 2 wkly; further doses given 4 wkly depending on toxicity. Neuroblastoma 100-240 mg/m2 followed by autologous stem cell rescue if doses are >140 mg/m2. Intra-arterial Melanoma; Soft tissue sarcoma Upper extremity perfusions: 0.6-1 mg/kg. Lower extremity perfusions: 0.8-1.5 mg/kg (melanoma) or 1-1.4 mg/kg (sarcoma).
Administration
Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
Contraindications
Hypersensitivity. Severe bone marrow suppression. Pregnancy.
Special Precautions
Renal impairment. Lactation. Prior bone marrow suppression, prior chemotherapy or irradiation. May mask signs of infection e.g. fever and increased WBC. Elderly.
Adverse Reactions
Diarrhoea, stomatitis, vomiting; haemolytic anaemia, vasculitis, pulmonary fibrosis, hepatic disorders, suppression of ovarian function in premenopausal women, temporary or permanent sterility in male patients. Allergic reactions.
Potentially Fatal: Bone marrow suppression. Secondary malignancy, cardiac arrest. Anaphylaxis.
ATC Classification
L01AA03 - melphalan ; Belongs to the class of alkylating agents, nitrogen mustard analogues. Used in the treatment of cancer.
Disclaimer: This information is independently developed by CIMS based on melphalan from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by CIMSAsia.com
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