Menadione


Full Generic Medicine Info
Dosage/Direction for Use

Oral
Vitamin K deficiency
Adult: 10 mg every 6 hr.

Oral
Severe hypoprothrombinaemia
Adult: 10 mg 3-4 times daily.

Intravenous
Vitamin K deficiency
Adult: 0.03 mcg/kg/day.
Child: Infants: 1-5 mcg/kg/day.

Intramuscular
Severe hypoprothrombinaemia
Adult: 2.5-10 mg daily.
Special Precautions
Pregnancy. G6PD deficiency, vitamin E deficiency. Neonates, premature infants. Hepatic impairment. Monitor prothrombin time.
Adverse Reactions
Facial flushing, sweating, chest constriction/pain, dyspnoea, cyanosis, CV collapse. IM: Severe shock-like reactions, phlebitis, inj site reactions.
Potentially Fatal: Anaphylaxis.
Drug Interactions
Decreases effects of oral anticoagulants.
Action
Menadione is a synthetic lipid-soluble vitamin K analogue. It is an essential cofactor in the hepatic synthesis of prothrombin (factor II) and other blood clotting factors (factors VII, IX, X and proteins C and S), and in the function of proteins important for bone development (e.g. osteocalcin).
Absorption: Requires bile for absorption from the GI tract.
Distribution: Accumulates in the liver; does not appear to cross the placenta.
CIMS Class
ATC Classification
B02BA02 - menadione ; Belongs to the class of vitamin K. Used in the treatment of hemorrhage.
Disclaimer: This information is independently developed by CIMS based on menadione from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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