Menthol


Full Prescribing Info
Dosage/Direction for Use

Oral
Nasal congestion
Adult: As loz containing 8 mg levomenthol (including amylmetacresol and 2,4-dichlorobenzyl alcohol): Dissolve 1 loz slowly in the mouth 2-3 hourly. Max: 12 loz daily. Medical advice should be considered if symptoms persist or worsen. Contents, formulation, and dosing may vary among countries, refer to specific product guideline for detailed information.
Child: >6 years
Same as adult dose.

Oral
Cough
Adult: As 7.6 mg menthol loz: Dissolve 1 loz slowly in the mouth, may be repeated 2 hourly as needed or as prescribed. As loz containing 8 mg levomenthol (including amylmetacresol and 2,4-dichlorobenzyl alcohol): Dissolve 1 loz slowly in the mouth 2-3 hourly. Max: 12 loz daily. As syrup containing 2.5 mg/5 mL menthol (including dextromethorphan hydrobromide): 10 mL, may be repeated after 4 hours if necessary. Medical advice should be considered if symptoms persist or worsen. Contents, formulation, and dosing may vary among countries, refer to specific product guideline for detailed information.
Child: As loz containing 8 mg levomenthol (including amylmetacresol and 2,4-dichlorobenzyl alcohol): >6 years
Same as adult dose. As 7.6 mg loz or as syrup containing 2.5 mg/5 mL menthol (including dextromethorphan hydrobromide): ≥12 years Same as adult dose.

Oral
Sore throat
Adult: As 7.6 mg menthol loz: Dissolve 1 loz slowly in the mouth, may be repeated 2 hourly as needed or as prescribed. As loz containing 8 mg levomenthol (including amylmetacresol and 2,4-dichlorobenzyl alcohol): Dissolve 1 loz slowly in the mouth 2-3 hourly. Max: 12 loz daily. Medical advice should be considered if symptoms persist or worsen. Contents, formulation, and dosing may vary among countries, refer to specific product guideline for detailed information.
Child: As loz containing 8 mg levomenthol (including amylmetacresol and 2,4-dichlorobenzyl alcohol): >6 years
Same as adult dose. As 7.6 mg menthol loz: ≥12 years Same as adult dose.

Inhalation
Nasal congestion
Adult: As solution for vapour inhalation containing 17.5% w/v menthol (including peppermint oil): Sprinkle few drops on a handkerchief, then inhale the vapour. As solution for vapour inhalation containing 2% w/v menthol (including eucalyptus oil): Add 5 mL to a pint of hot (not boiling) water then inhale the vapour, may be repeated 4 hourly if necessary. As nasal stick containing 40% w/w levomenthol (including cajuput oil, peppermint oil, and eucalyptus oil): Insert into each nostril then inhale for up to 4 times per hour. Medical advice should be considered if symptoms persist or worsen. Contents, formulation, and dosing may vary among countries, refer to specific product guideline for detailed information.
Child: As solution for vapour inhalation containing 2% w/v menthol (including eucalyptus oil): >3 months
Same as adult dose. As solution for vapour inhalation containing 17.5% w/v menthol (including peppermint oil): >2 years Same as adult dose. As nasal stick containing 40% w/w levomenthol (including cajuput oil, peppermint oil, and eucalyptus oil): ≥6 years Same as adult dose.

Topical/Cutaneous
Musculoskeletal pain
Adult:
As 2% or 4% w/w gel or 5% patch: Apply onto the affected area 3-4 times daily. As cream or ointment (usually in combination with camphor, eucalyptus oil, or methyl salicylate): Apply and rub gently onto the affected area 2-3 times daily. As spray containing menthol alone or usually in combination with methyl salicylate: Spray onto the affected area, may repeat up to 3-4 times daily. Medical advice should be considered if symptoms persist or worsen. Contents, formulation, and dosing may vary among countries, refer to specific product guideline for detailed information.
Child: As ointment: ≥2 years
Same as adult dose. As 2% w/w gel: >5 years Same as adult dose. As spray, cream, or patch: >12 years Same as adult dose.
Contraindications
Hypersensitivity. Topical: Application on damaged or irritated skin, sensitive skin, serious burns, and wounds; tight covering or bandages on the site of application.
Special Precautions
Patient with persistent or chronic cough associated with smoking, asthma or emphysema; cough with excessive mucus (oral). Children. Pregnancy and lactation. Patient Counselling Topical: Avoid contact with mucous membranes, application into nostrils, and application of heat to the affected area. Solution for vapour inhalation: Avoid direct application into the nostrils particularly in infants and young children; avoid contact with the eyes or skin.
Adverse Reactions
Significant: Hypersensitivity reactions (e.g. contact dermatitis, flushing). Topical: Serious burns (e.g. 1st- to 3rd-degree burns) or burning sensation at the application site. Nervous system disorders: Headache. Skin and subcutaneous tissue disorders: Skin irritation.
Overdosage
Symptoms: Oral: Gastrointestinal disturbances (e.g. nausea, vomiting, severe abdominal pain, diarrhoea), and CNS effects (e.g. drowsiness, vertigo, ataxia). Inhalation: Confusion, ataxia, euphoria, diplopia, and nystagmus. Management: Symptomatic and supportive treatment.
Action
Menthol exhibits a mild local anaesthetic activity on the throat and the nasal mucosa to relieve symptoms of cough and nasal congestion. Additionally, it dilates the blood vessels which causes a sensation of coldness followed by an analgesic effect.
Absorption: Rapidly absorbed from the gastrointestinal tract; well absorbed through the skin.
Metabolism: Metabolised mainly in the liver via hydroxylation then undergoes conjugation with glucuronide.
Excretion: Via urine and bile (as glucuronide).
Storage
Inhalation: Store below 25°C. Storage may vary among products and countries, refer to specific product guideline for further information. Oral: Store below 25°C. Storage may vary among products and countries, refer to specific product guideline for further information. Topical/Cutaneous: Store below 25°C. Storage may vary among products and countries, refer to specific product guideline for further information.
Disclaimer: This information is independently developed by CIMS based on menthol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by CIMSAsia.com
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