Meprobamate


Full Prescribing Info
Dosage/Direction for Use

Oral
Short-term management of anxiety
Adult: 400 mg 3-4 times a day. Max: 2,400 mg daily.
Elderly: Up to 200 mg 3-4 times a day.
Contraindications
Hypersensitivity. Drug dependence (e.g. alcohol). Acute intermittent porphyria, acute pulmonary insufficiency, resp depression. Pregnancy and lactation.
Special Precautions
Patient w/ suicidal ideation, depression, seizure disorders (e.g. epilepsy), history of drug abuse or acute alcoholism, resp disease or muscle weakness. Avoid abrupt withdrawal. Renal and hepatic impairment. Elderly or debilitated patients. Patient Counselling This drug may cause drowsiness or dizziness, if affected, do not drive or operate machinery. Monitoring Parameters Monitor for anxiety symptoms, mental status, CNS depression, drug abuse, overuse, tolerance and dependence. Assess for history of addiction.
Adverse Reactions
Significant: Dependence, hypersensitivity reactions (e.g. skin rashes; rarely, anaphylaxis, angioedema, bronchospasm, exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome). Nervous: Drowsiness, dizziness, overstimulation, euphoria, slurred speech, vertigo, headache, paradoxical excitement, paraesthesia, ataxia. CV: Hypotension, arrhythmia, tachycardia, palpitation, transient ECG changes, syncope, peripheral oedema. GI: Transient nausea, vomiting, diarrhoea, stomatitis, proctitis, anorexia. Genitourinary: Anuria, oliguria. Ophthalmologic: Visual disturbances. Others: Chills, fever.
Potentially Fatal: Withdrawal symptoms (e.g. delirium tremens, tremors, muscle twitching, insomnia, confusion; rarely, convulsions); rarely, hypertensive crisis, bullous dermatitis, agranulocytosis, aplastic anaemia, thrombocytopenic purpura.
Overdosage
Symptoms: Drowsiness, lethargy, stupor, ataxia, coma, shock, vasomotor and resp collapse. Management: Supportive and symptomatic treatment. Maintain adequate airway, assisted respiration, and cautious admin of vasopressor agents if indicated. May perform gastric lavage in comatose, having seizure or lacks gag reflex patient if an inflated endotracheal tube cuff is inserted or induce emesis if patient is conscious. Admin of activated charcoal after gastric lavage/emesis for complete gastric emptying. Forced diuresis w/ an osmotic diuretic (e.g. mannitol) or peritoneal dialysis may be beneficial. Monitor urinary output and avoid overhydration.
Drug Interactions
Increased sedative effects w/ CNS depressants and psychotropic agents.
Food Interaction
Additive sedative effect w/ alcohol.
Lab Interference
Falsely high urinary 17-ketosteroid and 17 ketogenicsteroid concentration in Zimmerman reaction and 17-hydroxycorticosteroid concentration in modified Glenn-Nelson technique.
Action
Meprobamate is a carbamate derivative w/ CNS depressant action similar to barbiturates. The exact mechanism of action is still unknown. It acts in the thalamus and limbic system, and appears to inhibit multineuronal spinal reflexes. It also has hypnotic, sedative and some muscle relaxant properties.
Onset: Sedation: Approx 1 hr.
Absorption: Readily absorbed from the GI tract. Time to peak plasma concentration: 1-3 hr.
Distribution: Widely distributed. Crosses placenta and enters breast milk. Plasma protein binding: Approx 20%.
Metabolism: Extensively metabolised in the liver.
Excretion: Mainly via urine (8-20% as unchanged drug); faeces (10% as metabolites). Elimination half-life: 6-17 hr.
Storage
Oral: Store at 25°C.
CIMS Class
ATC Classification
N05BC01 - meprobamate ; Belongs to the class of carbamates anxiolytics. Used in the management of anxiety, agitation or tension.
Disclaimer: This information is independently developed by CIMS based on meprobamate from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by CIMSAsia.com
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