Mesterolone


Full Prescribing Info
Dosage/Direction for Use

Oral
Androgen deficiency, Infertility due to hypogonadism
Adult: Male: Initially, 75-100 mg daily in 3 or 4 divided doses for several mth. Maintenance: 50-75 mg daily in divided doses.
Administration
May be taken with or without food.
Contraindications
Current or history of hepatic tumours. Prostatic carcinoma.
Special Precautions
Not suitable for increasing muscular development and physical ability. Monitoring Parameters Regularly monitor prostate status.
Adverse Reactions
Significant: Frequent or persistent erections.
Action
Mesterolone supplements endogenous androgens w/ less inhibitory effect on intrinsic testicular function than testosterone and its derivatives.
Absorption: Rapidly and almost completely absorbed from the GI tract. Absolute bioavailability: Approx 3%. Time to peak plasma concentration: Approx 1.6 hr.
Distribution: Plasma protein binding: 98% (40% to albumin, 58% to sex hormone binding globulin).
Metabolism: Rapidly metabolised to 1α-methyl-androsterone, 1α-methyl-5α-androstane-3α, 17β-diol and other metabolites.
Excretion: Via urine (approx 77% as metabolites) and faeces (approx 13% as metabolites). Terminal half-life: 12-13 hr.
ATC Classification
G03BB01 - mesterolone ; Belongs to the class of 5-androstanon (3) derivative androgens used in androgenic hormone preparations.
Disclaimer: This information is independently developed by CIMS based on mesterolone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by CIMSAsia.com
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