Metacycline


Generic Medicine Info
Contraindications
Hypersensitivity. Pregnancy and lactation. Children ≤12 yr.
Special Precautions
Avoid direct sunlight. Renal and hepatic impairment.
Adverse Reactions
Hypersensitivity reactions, urticaria, photosensitivity, fever, epigastric pain, anorexia, nausea, vomiting, diarrhoea, oral candidiasis, vulvovaginitis, glossitis, pruritus ani, increased intracranial pressure, teeth and nail discolouration, renal dysfunction, hepatomegaly, enamel hypoplasia, neuromuscular blockade.
Potentially Fatal: Anaphylaxis. Severe renal impairment, fatty liver.
Drug Interactions
Absorption reduced by divalent and trivalent cations (e.g. aluminium, bismuth, calcium, iron, magnesium, zinc), sodium bicarbonate, colestipol, colestyramine, kaolin-pectin. May form complex with strontium ranelate. Increased nephrotoxic effects with diuretics, methoxyflurane, other nephrotoxic drugs. Additive hepatotoxicity with potentially hepatotoxic drugs. May increase incidence of benign intracranial hypertension with retinoids. May increase concentrations of lithium, digoxin, halofantrine, theophylline. May increase effects of oral anticoagulants, ergot alkaloids and methotrexate. May reduce plasma levels of atovaquone. May decrease the effectiveness of oral contraceptives. Possible antagonism with penicillins.
CIMS Class
Tetracyclines
ATC Classification
J01AA05 - metacycline ; Belongs to the class of tetracyclines. Used in the systemic treatment of infections.
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