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Indications/Uses
Listed in Dosage.
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Dosage/Direction for Use
Adult: PO Oedema 2.5-5 mg once daily, in the morning. Max: 10 mg/day. HTN 2.5-5 mg once daily, either alone or w/ other antihypertensives.
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Contraindications
Hypersensitivity to sulfonamide-derived drugs, anuria.
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Special Precautions
Patient w/ fluid and electrolyte disturbances, gout, DM, hypercholesterolaemia, parathyroid disease, history of allergy and bronchial asthma. May exacerbate SLE. Hepatic and renal impairment. Pregnancy and lactation. Monitoring Parameters Assess wt, input and output reports daily to determine fluid loss, BP, serum electrolytes, BUN, creatinine.
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Adverse Reactions
Headache, cramping, weakness, orthostatic hypotension, pancreatitis, jaundice, sialadenitis, vomiting, diarrhoea, nausea, gastric irritation, constipation, anorexia, aplastic anaemia, haemolytic anaemia, agranulocytosis, leukopenia, thrombocytopenia, anaphylactic reactions, necrotising angiitis, Stevens-Johnson syndrome, resp distress, fever, purpura, urticaria, rash, photosensitivity, hyperglycemia, hyperuricemia, electrolyte imbalance, vertigo, dizziness, paraesthesia, muscle spasm, restlessness, transient blurred vision, xanthopsia, glycosuria.
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B
D if used in gestational HTN.
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Drug Interactions
Increased risk of lithium toxicity. Hypokalaemia may develop during concomitant use of steroids or ACTH. Insulin requirement in DM patients may be altered. Decreased arterial responsiveness to norepinephrine. Increased responsiveness to tubocurarine. Potentiation of orthostatic hypotension by barbiturates or narcotics.
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CIMS Class
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ATC Classification
C03AA08 - methyclothiazide ; Belongs to the class of low-ceiling thiazide diuretics.
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