Methylergometrine


Full Generic Medicine Info
Dosage/Direction for Use

Oral
Postpartum haemorrhage
Adult: During the puerperium: 0.2 mg 3 or 4 times daily for 1 week.

Parenteral
Postpartum haemorrhage
Adult: After delivery of the anterior shoulder or placenta, or during the puerperium: 0.2 mg via IM inj. Doses may be repeated every 2-4 hours as necessary. In emergencies, the same dose may be given via slow IV infusion over 1 minute.
Contraindications
Hypersensitivity, hypertension, preeclampsia. Pregnancy.
Special Precautions
Patient with sepsis, coronary artery disease (CAD), obliterative vascular disease. Use during the second stage of labour. Renal and hepatic impairment. Lactation. Monitoring Parameters Monitor blood pressure, CNS status, and vaginal bleeding.
Adverse Reactions
Significant: Hypertension, myocardial ischaemia, MI; ergotism, pleural fibrosis, retroperitoneal fibrosis (prolonged use). Cardiac disorders: Chest pain, bradycardia, tachycardia, palpitation, coronary arterial spasm. Ear and labyrinth disorders: Tinnitus. Gastrointestinal disorders: Nausea, vomiting, diarrhoea, abdominal pain. Immune system disorders: Anaphylaxis. Metabolism and nutrition disorders: Water intoxication. Musculoskeletal and connective tissue disorders: Leg cramps. Nervous system disorders: Dizziness, headache, dysgeusia, seizure. Psychiatric disorders: Hallucination. Renal and urinary disorders: Haematuria. Respiratory, thoracic and mediastinal disorders: Dyspnoea, nasal congestion. Skin and subcutaneous tissue disorders: Rash, diaphoresis. Vascular disorders: Vasoconstriction, vasospasm, thrombophlebitis., hypotension.
Overdosage
Symptoms: Nausea, vomiting, abdominal pain, oliguria, tingling of the extremities, high blood pressure; hypotension, respiratory depression, hypothermia, convulsions. Management: Symptomatic and supportive treatment. Remove offending drug by inducing emesis, gastric lavage, catharsis, or supportive diuresis. Maintain adequate pulmonary ventilation, especially if convulsion or coma develop. Use standard anticonvulsant agents to control convulsion. Correct hypotension with pressor drugs. Treat peripheral vasospasm by applying warmth to the extremities as necessary.
Drug Interactions
Increased risk of ergot toxicity with CYP3A4 inhibitors (e.g. erythromycin, clarithromycin, ritonavir, delavirdine, ketoconazole, itraconazole, voriconazole). Enhance vasoconstrictive effect with β-blockers. Diminished therapeutic effect with anaesthetics (e.g. halothane, methoxyflurane). Reduced therapeutic effect of glyceryl trinitrate and other antianginal medications.
Action
Methylergometrine is an ergot alkaloid. It increases the tone, rate and amplitude of uterine contractions which shortens the third stage of labour and reduces blood loss. Synonym: methylergonovine.
Onset: 5-10 minutes (oral); 2-5 minutes (IM).
Duration: Approx 3 hours (oral/IM).
Absorption: Rapidly absorbed. Bioavailability: 60% (oral); 78% (IM). Time to peak plasma concentration: 0.3-2 hours (oral); 0.2-0.6 hours (IM).
Distribution: Enters breast milk. Volume of distribution: 39-73 L.
Metabolism: Undergoes extensive first-pass hepatic metabolism.
Excretion: Via the urine and faeces. Elimination half-life: Approx 3 hours.
Storage
Oral: Store between 20-25°C. Parenteral: Store between 2-8°C. Protect from light.
ATC Classification
G02AB01 - methylergometrine ; Belongs to the class of ergot alkaloids. Used to induce abortion or augment labour and to minimize blood loss from the placental site.
Disclaimer: This information is independently developed by CIMS based on methylergometrine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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