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Indications/Uses
Listed in Dosage.
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Dosage/Direction for Use
Adult: Ophth Ocular HTN; Open-angle glaucoma As 0.1% or 0.3% drops: Instill 1 drop bid into the affected eye.
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Contraindications
Bronchial asthma or history of bronchial asthma, severe COPD, symptomatic sinus bradycardia, 2nd or 3rd degree AV block, cardiogenic shock, overt cardiac failure.
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Special Precautions
Patients w/ myasthenia gravis, a history of cardiac failure or psychiatric disease, DM, cerebrovascular insufficiency, peripheral vascular disease including Raynaud's syndrome. Avoid abrupt withdrawal in patients undergoing elective surgery. May mask certain signs and symptoms of hyperthyroidism. Pregnancy and lactation. Patient Counselling Metipranolol contains benzalkonium Cl which may be absorbed by soft contact lenses. Remove lens prior to admin and wait 15 min before reinserting.
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Adverse Reactions
Transient local discomfort, abnormal vision, conjunctivitis, conjunctival leucoplakia, blepharitis, blurred vision, browache, oedema, eyelid dermatitis, photophobia, tearing, uveitis; hypersensitivity reaction, rash, angina, atrial fibrillation, MI, palpitation, bradycardia, anxiety, depression, HTN, dizziness, headache, nervousness, somnolence, asthenia, arthritis, myalgia, bronchitis, cough, dyspnoea, rhinitis, epistaxis, nausea.
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Drug Interactions
Potential additive effects on systemic β-blockade w/ oral β-blockers. Possible additive hypotensive effects or bradycardia w/ catecholamine-depleting drugs (e.g. reserpine). Possible precipitation of left ventricular failure w/ Ca channel blockers. Concomitant use w/ digitalis and Ca channel blockers may prolong AV conduction time.
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CIMS Class
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ATC Classification
S01ED04 - metipranolol ; Belongs to the class of beta blocking agents. Used in the treatment of glaucoma.
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