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Contraindications
Hypersensitivity, blood dyscrasias, active CNS disease, serious neurological disease, neurological disease, seizures, alcohol, children, convulsions
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Special Precautions
Pregnancy, lactation renal/hepatic impairment. H/O convulsions. Ensure adequate hydration, urinary output. Patients predisposed to seizures.
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Adverse Reactions
Peripheral neuropathies. GI disturbances, rash, urticaria, pruritus, superinfection (candida), metallic taste, headache, dizziness, transient leucopaenia, paraesthesias, tongue, glossitis, pseudomembranous colitis (rare). Reduced serum levels of cholesterol, and triglycerides, nausea, vomiting, heart burn, constipation/diarrhoea, headache, dizziness, depression, insomnia, dry mouth, fever, arthralgia and anaemia. Elevated liver enzymes, urea and creatinine.
Potentially Fatal: Seizures, eosinophilia, neutropaenia, thrombocytopaenia. |
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Drug Interactions
Acute psychoses when metronidazole co-administered with disulfiram. It has additive/synergistic effect with other antimicrobials. Blood levels increased by cimetidine. Antacids reduce absorption of norfloxacin from GIT.
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CIMS Class
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ATC Classification
J01MA06 - norfloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
A01AB17 - metronidazole ; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth. S01AE02 - norfloxacin ; Belongs to the class of quinolone antiinfectives. Used in the treatment of eye infections. P01AB01 - metronidazole ; Belongs to the class of nitroimidazole derivatives antiprotozoals. Used in the treatment amoebiasis and other protozoal diseases. J01XD01 - metronidazole ; Belongs to the class of imidazole derivative antibacterials. Used in the systemic treatment of infections. D06BX01 - metronidazole ; Belongs to the class of other topical chemotherapeutics used in the treatment of dermatological diseases. G01AF01 - metronidazole ; Belongs to the class of imidazole derivative antiinfectives. Used in the treatment of gynecological infections. |
