Midecamycin


Full Prescribing Info
Dosage/Direction for Use

Oral
Susceptible infections
Adult: As acetate: 0.9-1.8 g daily in 2-3 divided doses.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Patients who previously developed liver disorders while receiving the drug.
Special Precautions
Hepatic or renal impairment; prolongation of QT interval; porphyria; pregnancy; lactation.
Adverse Reactions
GI disturbances; hypersensitivity reactions; cholestatic jaundice; CV effects; myasthenia-like syndrome.
Drug Interactions
Other drugs known to prolong QT interval. May reduce effect of oral contaceptives. Concentration possibly increased by cimetidine. Increased plasma concentration of warfarin, digoxin, theophylline, carbamazepine, ciclosporin. Increased risk of peripheral ischaemia with ergotamine.
Potentially Fatal: Ventricular arrhythmias with astemizole, terfenadine and cisapride.
Action
Midecamycin binds reversibly to 50S ribosomal subunit causing blockade of transpeptidation/translocation reactions, inhibition of protein synthesis and thus inhibition of cell growth. Midecamycin has similar uses to erythromycin but is less active.
CIMS Class
ATC Classification
J01FA03 - midecamycin ; Belongs to the class of macrolides. Used in the systemic treatment of infections.
Disclaimer: This information is independently developed by CIMS based on midecamycin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by CIMSAsia.com
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