Milrinone


Generic Medicine Info
Contraindications
Severe obstructive aortic or pulmonary valvular disease or hypertrophic subaortic stenosis in lieu of surgical relief of obstruction; severe hypovolaemia.
Special Precautions
Patients with CV disease, electrolyte imbalance (e.g. hypokalaemia). Not recommended for use in patients with acute MI. Renal impairment. Pregnancy and lactation. Monitoring Parameters Monitor blood pressure, heart rate, ECG, electrolyte level (e.g. K, Mg) and fluid balance, renal function (e.g. serum creatinine), platelet count. Assess for signs of decreasing cardiac function (e.g. arrhythmia, hypotension).
Adverse Reactions
Significant: Ventricular arrhythmias (e.g. nonsustained ventricular tachycardia, sustained ventricular tachycardia, ventricular ectopy, ventricular fibrillation, supraventricular arrhythmias, supraventricular tachycardia), hypotension. Blood and lymphatic system disorders: Thrombocytopenia, anaemia. Cardiac disorders: Angina pectoris, atrial fibrillation, torsades de pointes. General disorders and administration site conditions: Injection site reaction. Investigations: Abnormal LFT. Metabolism and nutrition disorders: Hypokalaemia. Nervous system disorders: Headache, tremors. Respiratory, thoracic and mediastinal disorders: Bronchospasm. Skin and subcutaneous tissue disorders: Rash.
Potentially Fatal: Very rarely, anaphylactic shock.
Drug Interactions
Adverse effects may be enhanced when given concomitantly with anagrelide. May increase the hypotensive effect of riociguat.
CIMS Class
Cardiac Drugs
ATC Classification
C01CE02 - milrinone ; Belongs to the class of phosphodiesterase inhibitors. Used in the treatment of heart failure.
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