Mivacurium chloride


Generic Medicine Info
Contraindications
Patients known or suspected to be homozygous for the atypical plasma cholinesterase gene.
Special Precautions
Clinically significant CV disease. Any history of greater sensitivity to the release of histamine or related mediators (e.g. asthma); assure adequate hydration and carefully monitor haemodynamic status. Obese patients. Neuromuscular diseases (e.g. myasthenia gravis and the myasthenic syndrome). Burn patients. Fluid and electrolyte abnormalities. Renal or hepatic impairment. Reduced plasma cholinesterase activity. Pregnancy and lactation.
Adverse Reactions
Cutaneous flushing, mild hypotension, moderate wheezing; tachycardia, bradycardia, phlebitis; bronchospasm, hypoxaemia; rash, inj site reaction; dizziness; prolonged drug effect; muscle spasms.
Potentially Fatal: Anaphylactoid reactions, cardiac arrhythmias.
Drug Interactions
Effects may be increasead by aminoglycosides, clindamycin, calcium-channel blockers, colistin, enflurane, halothane, isoflurane, potassium-depleting diuretics, ketamine, lidocaine, sodium colistimethate, magnesium salts, polymyxin B, procainamide, quinidine, tetracyclines, opioid analgesics, suxamethonium, vancomycin. Effect may be reduced by carbamazepine, phenytoin (chronic use), corticosteroids, calcium and theophylline.
ATC Classification
M03AC10 - mivacurium chloride ; Belongs to the class of other quaternary ammonium-containing agents used as peripherally-acting muscle relaxants.
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