Molindone


Full Prescribing Info
Dosage/Direction for Use

Oral
Schizophrenia
Adult: As hydrochloride: Initially, 50-75 mg daily in 3-4 divided doses; may be increased to 100 mg daily after 3 or 4 days. Maintenance: Mild symptoms: 5-15 mg 3-4 times daily. Moderately severe symptoms: 10-25 mg 3-4 times daily. Severe symptoms: Up to 225 mg daily. A single daily dose is often adequate for maintenance therapy. Patients with resistant mental and emotional disturbances may require wk or mth of treatment.
Elderly: and debilitated: Reduce dose.
Contraindications
Coma, severe CNS depression.
Special Precautions
CNS depression. Parkinson's disease. Patients with haemodynamic instability; bone marrow suppression; predisposition to seizures; subcortical brain damage; severe cardiac, hepatic, renal, respiratory disease. Patients at risk of pneumonia. Breast cancer or other prolactin-dependent tumours. May alter temperature regulation or mask toxicity of other drugs. Patients at risk of orthostatic hypotension. Decreased GI motility, urinary retention, benign prostatic hyperplasia, xerostomia or visual problems. May impair ability to drive or operate machinery. Pregnancy and lactation.
Adverse Reactions
Orthostatic hypotension, tachycardia, arrhythmia; extrapyramidal reactions, mental depression, altered central temperature regulation, sedation, drowsiness, restlessness, anxiety, hyperactivity, euphoria, seizure; pruritus, rash, photosensitivity; menstrual irregularities, oedema of breasts, galactorrhoea, gynaecomastia; constipation, xerostomia, nausea, salivation, wt gain/loss; urinary retention, priapism; leukopenia, leukocytosis; blurred vision, retinal pigmentation; decreased diaphoresis.
Potentially Fatal: Neuroleptic malignant syndrome (NMS).
Overdosage
Symptoms: Deep sleep, extrapyramidal symptoms, cardiac arrhythmias, seizures, hypotension. Management: Symptom-directed and supportive.
Drug Interactions
Increased risk of antipsychotic-related extrapyramidal symptoms with central acetylcholinesterase inhibitors, metoclopramide. Therapeutic response may be inhibited by anticholinergics (e.g. benztropine, trihexyphenidyl, biperiden, TCAs, antihistamines, disopyramide) and anticholinergic crisis may occur. May have additive hypotensive effects with antihypertensive agents, trazodone. May inhibit the effect of bromocriptine on prolactin levels. May cause additive sedation with barbiturates, benzodiazepines, opioid analgesics, ethanol. May produce neurotoxicity with lithium. Serum concentration may be increased with propranolol, sulfadoxine-pyrimethamine.
Potentially Fatal: Amphetamines may increase psychotic symptoms; may reduce efficacy of amphetamines. May inhibit antiparkinsonian effect of levodopa.
Food Interaction
Additive CNS depression may occur with kava kava, gotu kola, valerian, St John's wort.
Action
Molindone is a dihydroindoline antipsychotic with general properties similar to those of chlorpromazine.
Duration: 24-36 hr.
Absorption: Readily absorbed after oral doses; peak concentrations of unchanged drug within about 1.5 hr.
Metabolism: Hepatic; rapidly and extensively metabolised.
Excretion: Via urine and faeces (mainly as metabolites and <2-3% as unchanged drug). Elimination half-life: 1.5 hr.
Storage
Oral: Store at 25°C (77°F). Protect from light.
CIMS Class
ATC Classification
N05AE02 - molindone ; Belongs to the class of indole derivatives antipsychotics.
Disclaimer: This information is independently developed by CIMS based on molindone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by CIMSAsia.com
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