Mometasone

Listed in Dosage.

Adult: Inhalation Asthma prophylaxis As dry powd inhaler: Mild to moderate: Initial: 400 mcg once daily in the evening. Maintenance: 200 mcg 1-2 times/day. Severe: Initial: 400 mcg bid, titrated to the lowest effective dose once symptoms are controlled. Nasal Allergic rhinitis As 0.05% susp: 100 mcg into each nostril once daily, up to 200 mcg into each nostril daily if needed. Nasal polyps 100 mcg into each nostril once daily, increased to bid after 5-6 wk if needed. Topical Corticosteroid-responsive dermatoses As 0.1% cream/oint: Apply thinly to affected area once daily. As 0.1% lotion: Apply a few drops to affected area once daily.

Patient w/ heart failure, DM, GI disorders, myasthenia gravis, acute MI, cataracts/glaucoma, thyroid disease; history of seizure disorders; untreated localised infection of the nasal mucosa (e.g. herpes simplex), recent nasal surgery/trauma; patient w/ or at risk of osteoporosis. Patient w/ facial rosacea, acne vulgaris, skin atrophy, perioral dermatitis, perianal/genital pruritis, napkin eruptions; bacterial, viral, parasitical and fungal infections; varicella, syphilis or post-vaccine reactions. Avoid abrupt withdrawal when switching from systemic to oral or orally inhaled corticosteroid. Hepatic and renal impairment. Pregnancy and lactation. Monitoring Parameters Monitor pulmonary function, signs/symptoms of candidiasis, ocular effects.

Hypothalmic-pituitary-adrenal (HPA) axis suppression, immunosuppression, Kaposi sarcoma, oral candidiasis, psychiatric disturbances, headache, allergic rhinitis, pharyngitis, upper resp tract infection, sinusitis, dysmenorrhoea, musculoskeletal pain, back pain, dyspepsia, myalgia, abdominal pain, nausea.
Potentially Fatal: Paradoxical bronchospasm, anaphylaxis.

Strong CYP3A4 inhibitors (e.g. ketoconazole) may increase systemic exposure of mometasone.

Topical Corticosteroids / Nasal Decongestants & Other Nasal Preparations / Antiasthmatic & COPD Preparations

D07AC13 - mometasone ; Belongs to the class of potent (group III) corticosteroids. Used in the treatment of dermatological diseases.
D07XC03 - mometasone ; Belongs to the class of potent (group III) corticosteroids in other combinations. Used in the treatment of dermatological diseases.
R03BA07 - mometasone ; Belongs to the class of other inhalants used in the treatment of obstructive airway diseases, glucocorticoids.
R01AD09 - mometasone ; Belongs to the class of topical corticosteroids used for prophylaxis and treatment of allergic rhinitis.