Moxifloxacin


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult: PO Community-acquired pneumonia 400 mg once daily for 10 days. Acute bacterial sinusitis 400 mg once daily for 7 days. Acute bacterial exacerbation of chronic bronchitis 400 mg once daily for 5-10 days. Complicated skin and skin structure infections 400 mg once daily for 7-21 days. Uncomplicated skin and skin structure infections 400 mg once daily for 7 days. Pelvic inflammatory disease Combined with another antibacterial agent in mild to moderate cases: 400 mg once daily for 14 days. IV Community-acquired pneumonia 400 mg once daily for 7-14 days. Complicated intra-abdominal infections 400 mg once daily for 5-14 days. Acute bacterial sinusitis 400 mg once daily for 10 days. Acute bacterial exacerbation of chronic bronchitis 400 mg once daily for 5 days. Complicated skin and skin structure infections 400 mg once daily for 7-21 days. Uncomplicated skin and skin structure infections 400 mg once daily for 7 days. Plague 400 mg once daily for 10-14 days. Administer via infusion over 60 minutes. Ophth Bacterial conjunctivitis As 0.5% solution: Instill 1 drop into the affected eye(s) tid for 7 days.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to moxifloxacin or other quinolone antibiotics. Patient with history of tendon disorders, myasthenia gravis, QT interval prolongation, ventricular arrhythmias, proarrhythmic conditions (e.g. bradycardia, acute MI), peripheral neuropathy, uncorrected electrolyte disorders (e.g. hypokalaemia, hypomagnesemia). Concomitant use with Class 1A and Class III antiarrhythmics, antihistamines, and other drugs that prolong QT interval (e.g. cisapride, erythromycin, antipsychotics, and TCA).
Special Precautions
Patient with known or suspected CNS disorders (e.g. seizure disorder) or other risk factors predisposing to seizures, solid organ transplant recipients, significant bradycardia or acute myocardial ischaemia, diabetes mellitus, rheumatoid arthritis, G6PD, psychiatric disease. Renal and hepatic impairment. Elderly. Pregnancy and lactation. Patient Counselling This drug may cause dizziness and transient loss of vision, if affected, do not drive or operate machinery. Avoid excessive exposure to sunlight or artificial UV light (e.g. tanning beds) and use protective measures (e.g. sunscreen, wear loose-fitting clothes) if staying outdoors during therapy. Remove contact lenses prior to ophth admin. Monitoring Parameters Monitor for hypersensitivity reactions, signs and symptoms of infection. Monitor CBC, ECG, LFT and blood glucose levels closely.
Adverse Reactions
Significant: Hypersensitivity reactions (e.g. anaphylaxis, shock). Superinfections, hyperglycaemia, pseudomembranous colitis or Clostridium difficile-associated diarrhoea, irreversible tendinitis, or tendon rupture, CNS effects (e.g. peripheral neuropathy, seizures, anxiety, depression, delirium, hallucination), leukopenia, neutropenia, thrombocytopenia. Blood and lymphatic system disorders: Anaemia. Ear and labyrinth disorders: Tinnitus. Eye disorders: Eye irritation, conjunctivitis, decreased visual acuity, eye pain and discomfort, eye pruritus, lacrimation, ocular hyperemia, subconjunctival haemorrhage, xerophthalmia. Gastrointestinal disorders: Nausea, vomiting, abdominal pain. General disorders and administration site conditions: Hyperhidrosis. Hepatobiliary disorders: Jaundice. Metabolism and nutrition disorders: Hyperlipidaemia, dehydration, anorexia. Musculoskeletal and connective tissue disorders: Arthralgia, myalgia. Nervous system disorders: Headache, dizziness, insomnia, confusion. Psychiatric disorders: Disturbances in attention, disorientation, agitation, nervousness, memory impairment. Skin and subcutaneous tissue disorders: Rash, pruritus. Vascular disorders: Vasculitis.
Potentially Fatal: Hypoglycaemia, fulminant hepatitis. Rarely, QT prolongation and ventricular arrhythmias (including torsades de pointes), bullous skin reactions (e.g. Stevens-Johnson syndrome, toxic epidermal necrolysis).
Drug Interactions
Increased risk of bradycardia with potassium-reducing agents (e.g. loop diuretics). Increased risk of tendon disorder with corticosteroids. Decreased absorption by forming chelates with antacids containing Al, Mg, Fe, sucralfate and multivalent cations. May enhance anticoagulant effects of warfarin.
ATC Classification
J01MA14 - moxifloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
S01AE07 - moxifloxacin ; Belongs to the class of quinolone antiinfectives. Used in the treatment of eye infections.
Disclaimer: This information is independently developed by CIMS based on moxifloxacin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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