Generic Medicine Info
May be taken with or without food.
Hypersensitivity to moxifloxacin or other quinolone antibiotics. Patient with history of tendon disorders, myasthenia gravis, QT interval prolongation, ventricular arrhythmias, proarrhythmic conditions (e.g. bradycardia, acute MI), peripheral neuropathy, uncorrected electrolyte disorders (e.g. hypokalaemia, hypomagnesemia). Concomitant use with Class 1A and Class III antiarrhythmics, antihistamines, and other drugs that prolong QT interval (e.g. cisapride, erythromycin, antipsychotics, and TCA).
Special Precautions
Patient with known or suspected CNS disorders (e.g. seizure disorder) or other risk factors predisposing to seizures, solid organ transplant recipients, significant bradycardia or acute myocardial ischaemia, diabetes mellitus, rheumatoid arthritis, G6PD, psychiatric disease. Renal and hepatic impairment. Elderly. Pregnancy and lactation. Patient Counselling This drug may cause dizziness and transient loss of vision, if affected, do not drive or operate machinery. Avoid excessive exposure to sunlight or artificial UV light (e.g. tanning beds) and use protective measures (e.g. sunscreen, wear loose-fitting clothes) if staying outdoors during therapy. Remove contact lenses prior to ophth admin. Monitoring Parameters Monitor for hypersensitivity reactions, signs and symptoms of infection. Monitor CBC, ECG, LFT and blood glucose levels closely.
Adverse Reactions
Significant: Hypersensitivity reactions (e.g. anaphylaxis, shock). Superinfections, hyperglycaemia, pseudomembranous colitis or Clostridium difficile-associated diarrhoea, irreversible tendinitis, or tendon rupture, CNS effects (e.g. peripheral neuropathy, seizures, anxiety, depression, delirium, hallucination), leukopenia, neutropenia, thrombocytopenia. Blood and lymphatic system disorders: Anaemia. Ear and labyrinth disorders: Tinnitus. Eye disorders: Eye irritation, conjunctivitis, decreased visual acuity, eye pain and discomfort, eye pruritus, lacrimation, ocular hyperemia, subconjunctival haemorrhage, xerophthalmia. Gastrointestinal disorders: Nausea, vomiting, abdominal pain. General disorders and administration site conditions: Hyperhidrosis. Hepatobiliary disorders: Jaundice. Metabolism and nutrition disorders: Hyperlipidaemia, dehydration, anorexia. Musculoskeletal and connective tissue disorders: Arthralgia, myalgia. Nervous system disorders: Headache, dizziness, insomnia, confusion. Psychiatric disorders: Disturbances in attention, disorientation, agitation, nervousness, memory impairment. Skin and subcutaneous tissue disorders: Rash, pruritus. Vascular disorders: Vasculitis.
Potentially Fatal: Hypoglycaemia, fulminant hepatitis. Rarely, QT prolongation and ventricular arrhythmias (including torsades de pointes), bullous skin reactions (e.g. Stevens-Johnson syndrome, toxic epidermal necrolysis).
Drug Interactions
Increased risk of bradycardia with potassium-reducing agents (e.g. loop diuretics). Increased risk of tendon disorder with corticosteroids. Decreased absorption by forming chelates with antacids containing Al, Mg, Fe, sucralfate and multivalent cations. May enhance anticoagulant effects of warfarin.
CIMS Class
Eye Anti-Infectives & Antiseptics / Quinolones
ATC Classification
J01MA14 - moxifloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
S01AE07 - moxifloxacin ; Belongs to the class of quinolone antiinfectives. Used in the treatment of eye infections.
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