Naftifine


Full Generic Medicine Info
Dosage/Direction for Use

Topical/Cutaneous
Tinea cruris
Adult: Apply to the affected area(s) and surrounding skin as 1% cream once daily or as 1% gel bid for up to 4 weeks. As 2% cream: Apply a thin layer once daily to the affected area(s) plus ½ inch margin to healthy surrounding skin for 2 weeks.
Child: As 2% cream: Tinea corporis: ≥2 years Same as adult dose. Tinea cruris: ≥12 years Same as adult dose.

Topical/Cutaneous
Tinea corporis
Adult: Apply to the affected area(s) and surrounding skin as 1% cream once daily or as 1% gel bid for up to 4 weeks. As 2% cream: Apply a thin layer once daily to the affected area(s) plus ½ inch margin to healthy surrounding skin for 2 weeks.
Child: As 2% cream: Tinea corporis: ≥2 years Same as adult dose. Tinea cruris: ≥12 years Same as adult dose.

Topical/Cutaneous
Tinea pedis
Adult: Apply to the affected area(s) and surrounding skin as 1% cream once daily or as 1% gel bid for up to 4 weeks. As 2% cream/gel: Apply a thin layer to the affected area(s) plus ½ inch margin of healthy surrounding skin once daily for 2 weeks.
Child: As 2% gel/cream: ≥12 years Same as adult dose.
Contraindications
Hypersensitivity.
Special Precautions
Pregnancy and lactation. Monitoring Parameters Perform culture and susceptibility tests or confirm diagnosis via direct microscopic examination of a KOH mounting of infected tissue; consult local institutional recommendations before treatment initiation due to antifungal resistance risks. Monitor for signs of application site reactions (e.g. exfoliation, erythema, dermatitis).
Adverse Reactions
Significant: Irritation, sensitivity. General disorders and administration site conditions: Application site reactions. Skin and subcutaneous tissue disorders: Burning, stinging sensation of the skin; dryness, erythema, itching.
Action
Naftifine is a synthetic allylamine with fungistatic and fungicidal activity. It inhibits squalene 2, 3-epoxidase which causes a decrease in ergosterol synthesis and consequently an increase in squalene cells.
Absorption: Systemically absorbed after topical application.
Excretion: Via urine and faeces (as unchanged drug and metabolites). Elimination half-life: 2-3 days.
Storage
Topical/Cutaneous: Store between 20-25°C. Storage recommendations may vary among individual products. Refer to specific product guidelines.
CIMS Class
Topical Antifungals & Antiparasites
ATC Classification
D01AE22 - naftifine ; Belongs to the class of other antifungals for topical use.
Disclaimer: This information is independently developed by CIMS based on naftifine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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