Nalmefene


Generic Medicine Info
Contraindications
Current or recent opioid addiction, acute opioid withdrawal symptoms, history of acute alcohol withdrawal syndrome. Severe hepatic and renal impairment. Concomitant use w/ opioid agonists (e.g. opioid analgesics, methadone) or partial agonists (e.g. buprenorphine).
Special Precautions
Patient w/ psychiatric comorbidity (e.g. major depressive disorder), history of seizure disorders. Intended for use only to patient w/ high drinking risk level, at least 2 wk after assessment. Mild or moderate renal and hepatic impairment. Pregnancy and lactation. Patient Counselling This drug may cause dizziness and somnolence, if affected, do not drive or operate machinery. Monitoring Parameters Assess clinical status, alcohol dependence, level of alcohol consumption before initiation of therapy.
Adverse Reactions
Significant: Psychiatric symptoms, alcoholic psychosis, alcohol withdrawal symptoms. Nervous: Dizziness, insomnia, headache, sleep disorder, confusional state, restlessness, somnolence, tremor, attention disturbance, paraesthesia, hypoaesthesia, fatigue, asthenia, malaise, abnormal feeling, hallucinations, dissociation. CV: Tachycardia, palpitation. GI: Nausea, decreased appetite, vomiting, dry mouth, diarrhoea. Endocrine: Decreased libido, wt decreased. Musculoskeletal: Muscle spasms. Dermatologic: Hyperhidrosis.
Drug Interactions
Increased exposure w/ UGT2B7 enzyme inhibitors (e.g. diclofenac, fluconazole). Decreased exposure w/ UGT2B7 enzyme inducers (e.g. dexamethasone, phenobarbital).
ATC Classification
N07BB05 - nalmefene ; Belongs to the class of drugs used in the management of alcohol dependence.
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