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Dosage/Direction for Use
Ophthalmic Ocular allergy Adult: As combination preparation containing naphazoline HCl 0.05% and antazoline phosphate 0.5% : Apply 1-2 drops in the affected eye 4 times daily. |
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Contraindications
Angle closure glaucoma.
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Special Precautions
Glaucoma, hypertension, CV abnormalities, DM, hyperthyroidism, infection, or injury. Pregnancy and lactation. Avoid in infants and young children <6 yr. Rebound congestion may occur with prolonged use or overuse. Medical advice should be sought if there is ocular pain, vision changes, worsening of redness or irritation of the eye or symptoms lasts > 72 hr. Remove contact lens before use.
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Adverse Reactions
Blurring of vision, mild stinging and/or irritation, mydriasis and increased or decreased intraocular pressure. When used in high doses in elderly, naphazoline may liberate pigment granules from the iris.
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Drug Interactions
Increased pressor effects with maprotiline or TCA. Possibility of severe hypertensive reaction with MAOI.
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Action
Naphazoline, an imidazoline derivative sympathomimetic with α-adrenergic activity, produces vasoconstriction. When applied topically to mucous membranes, it reduces swelling and congestion. It is often used in combination with antazoline, an ethylenediamine derivative antihistamine, in ophthalmic preparations. Antazoline may be used as the hydrochloride, phosphate, sulfate or mesilate salts in ophthalmic preprations, usually in a concentration of 0.5%.
Onset: Local vasoconstriction: within 10 minutes Duration: Local vasoconstriction: 2-6 hr |
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Storage
Ophthalmic: Store at 20-25°C (68-77°F). Protect from light.
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CIMS Class
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ATC Classification
R01AB02 - naphazoline ; Belongs to the class of topical sympathomimetic combination preparations, excluding corticosteroids. Used as nasal decongestants.
R01AC04 - antazoline ; Belongs to the class of topical antiallergic preparations, excluding corticosteroids. Used as antiallergic agents. R01AA08 - naphazoline ; Belongs to the class of topical sympathomimetic agents used as nasal decongestants. R06AX05 - antazoline ; Belongs to the class of other antihistamines for systemic use. S01GA01 - naphazoline ; Belongs to the class of sympathomimetics used as ophthalmologic decongestants. |
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