Naphazoline


Full Prescribing Info
Dosage/Direction for Use

Nasal
Nasal congestion
Adult: As 0.05% soln: 1-2 drops in each nostril up to 6 hrly for 3 days.
Child: ≥12 yr
Same as adult dose.

Ophthalmic
Conjunctival decongestant
Adult: As 0.1% soln: Instill 1-2 drops onto conjunctival sac 3-4 hrly, as needed.

Ophthalmic

Minor eye irritation
Adult: As 0.012% soln: Instill 1-2 drops into affected eye(s) bid or tid.
Child: ≥12 yr
Same as adult dose.
Contraindications
Ophth: Narrow-angle glaucoma, corneal damage, acute iritis and other serious eye disease.
Special Precautions
Patient w/ CV disease, HTN, DM, hyperthyroidism, local infection or injury. Childn. Pregnancy and lactation. Patient Counselling This drug may cause drowsiness, temporary blurred vision, and transient mydriasis, if affected, do not drive or operate machinery. Remove contact lenses prior to ophth admin and reinsert after 10-15 min.
Adverse Reactions
Significant: Rebound vasodilation or congestion (prolonged/frequent use). Nervous: Nervousness, headache, drowsiness, dizziness, weakness. GI: Nausea. CV: Cardiac irregularities, HTN. Resp: Burning, stinging, sneezing, increased discharge (nasal). Endocrine:Hyperglycaemia. Ophthalmologic: Mydriasis, ocular hyperaemia, increased redness, irritation, discomfort, blurred vision, punctuate keratitis, lacrimation, increased intraocular pressure. Dermatologic: Sweating.
Action
Naphazoline is an alpha adrenergic receptor agonist which causes vasoconstriction by stimulating arterioles of the conjunctiva and nasal mucosa thus reducing swelling, redness and discomfort when applied to mucous membranes.
Onset: Conjunctival vasoconstriction: W/in 10 min.
Duration: 2-6 hr.
Absorption: May be absorbed systemically.
Storage
Nasal: Store below 25°C. Ophthalmic: Store below 25°C.
ATC Classification
S01GA01 - naphazoline ; Belongs to the class of sympathomimetics used as ophthalmologic decongestants.
R01AB02 - naphazoline ; Belongs to the class of topical sympathomimetic combination preparations, excluding corticosteroids. Used as nasal decongestants.
R01AA08 - naphazoline ; Belongs to the class of topical sympathomimetic agents used as nasal decongestants.
Disclaimer: This information is independently developed by CIMS based on naphazoline from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by CIMSAsia.com
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