Natamycin

Ophthalmic
Fungal blepharitis
Adult: As 5% ophthalmic susp: Instill 1 drop into the conjunctival sac of the affected eye(s) 4-6 times daily.

Ophthalmic
Fungal conjunctivitis
Adult: As 5% ophthalmic susp: Instill 1 drop into the conjunctival sac of the affected eye(s) 4-6 times daily.

Ophthalmic
Fungal keratitis
Adult: As 5% ophthalmic susp: Instill 1 drop into the conjunctival sac of the affected eye(s) 1-2 hourly, reduce to 1 drop 6-8 times daily after 3-4 days. Duration of treatment: 2-3 weeks. Gradually reduce dose at 4-7 day intervals.

Hypersensitivity.

Patient with epithelial ulceration. Pregnancy and lactation. Patient Counselling Avoid use of contact lenses during treatment. Monitoring Parameters Assess for treatment effectiveness; if no improvement after 7-10 days, re-evaluate therapy.

Cardiac disorders: Chest pain. Eye disorders: Changes in vision, corneal opacity; eye discomfort, oedema, hyperaemia, irritation, pain, foreign body sensation, paraesthesia, tearing. Immune system disorders: Allergic reaction. Respiratory, thoracic and mediastinal disorders: Dyspnoea.

Natamycin, a tetraene polyene antifungal antibiotic with predominantly fungicidal activity, is derived from Streptomyces natalensis. It binds to the sterol moiety of the fungal cell membrane and alters the membrane permeability, thereby allowing the depletion of essential cellular contents.
Absorption: Not expected to be absorbed systemically (ophthalmic).
Distribution: Adheres onto cornea; retained in conjunctival fornices; does not produce effective intraocular fluid levels.

Ophthalmic: Store between 2-24°C. Do not freeze. Protect from excessive heat and light.

Antifungals / Eye Anti-Infectives & Antiseptics

S01AA10 - natamycin ; Belongs to the class of antibiotics. Used in the treatment of eye infections.
A01AB10 - natamycin ; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth.
G01AA02 - natamycin ; Belongs to the class of antibiotics. Used in the treatment of gynecological infections.
A07AA03 - natamycin ; Belongs to the class of antibiotics. Used in the treatment of intestinal infections.
D01AA02 - natamycin ; Belongs to the class of antibiotics. Used in the topical treatment of fungal infection.