Nedocromil


Full Prescribing Info
Dosage/Direction for Use

Inhalation
Chronic asthma
Adult: As metered-dose inhaler (2 mg/dose): Initially, 2 actuations 4 times daily. Dose may be reduced to bid, according to patient's response.
Child: ≥6 yr
Same as adult dose.

Ophthalmic
Allergic conjunctivitis
Adult: As 2% soln: Instill 1-2 drop into each eye bid, may be increased to 4 times daily, if necessary. Max treatment duration: 12 wk.
Child: ≥6 yr
Same as adult dose.

Ophthalmic
Vernal keratoconjunctivitis
Adult: As 2% soln: Instill 1 drop into each eye 4 times daily.
Child: ≥6 yr
Same as adult dose.
Special Precautions
Not intended for use in acute asthma attack. Avoid abrupt withdrawal. Childn. Pregnancy and lactation. Patient Counselling Remove contact lenses prior to ophth admin and reinsert after 10-15 min.
Adverse Reactions
Nervous: Headache. GI: Nausea, vomiting, abdominal pain, dysgeusia, dyspepsia. Resp: Cough, throat irritation, transient bronchospasm, pharyngitis, nasal congestion, rhinitis. Ophthalmologic: Burning, irritation, stinging, conjunctivitis, eye redness, photophobia.
Action
Nedocromil is a pyranoquinoline dicarboxylic acid derivative, a mast- cell stabiliser. It suppresses immediate and delayed allergic reaction by inhibiting activation of eosinophils and release of inflammatory chemotactic and smooth muscle contracting mediators (e.g. histamine, leukotrienes, prostaglandin), thus reduces bronchospasm, cough and bronchial hyperreactivity, improves measurements of lung function, and provides relief from ocular itching associated w/ allergic conjunctivitis.
Absorption: Approx 5 % is absorbed from the resp tract (inhalation). <4% is absorbed systemically (ophth). Time to peak plasma concentration: W/in 1 hr.
Distribution: Plasma protein binding: Approx 89%.
Excretion: Mainly via urine (70%, as unchanged drug); faeces (30%, as unchanged drug). Elimination half-life: Approx 1-3.3 hr.
Storage
Inhalation: Store below 30°C. Protect from direct sunlight. Ophthalmic: Store below 25°C.
ATC Classification
R03BC03 - nedocromil ; Belongs to the class of other inhalants used in the treatment of obstructive airway diseases, antiallergic agents.
R01AC07 - nedocromil ; Belongs to the class of topical antiallergic preparations, excluding corticosteroids. Used as antiallergic agents.
S01GX04 - nedocromil ; Belongs to the class of other ophthalmologic antiallergics.
Disclaimer: This information is independently developed by CIMS based on nedocromil from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by CIMSAsia.com
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