Neomycin


Generic Medicine Info
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to neomycin or other aminoglycosides. Intestinal obstruction, inflammatory or ulcerative gastrointestinal disease, myasthenia gravis. Infants <1 year.
Special Precautions
Patient with neuromuscular disorders, Parkinson's disease; hearing impairment; pre-existing vertigo, tinnitus, or hearing loss. Patient with m.1555A>G mitochondrial mutation. Renal and hepatic impairment. Pregnancy and lactation. Monitoring Parameters Monitor serum creatinine/BUN at baseline and periodically during chronic therapy; audiometry in symptomatic patients. Asses for ototoxicity, nephrotoxicity, and neurotoxicity.
Adverse Reactions
Significant: Neurotoxicity; malabsorption with steatorrhoea and diarrhoea, ototoxicity, superinfection (prolonged use). Blood and lymphatic system disorders: Haemolytic anaemia, eosinophilia, Gastrointestinal disorders: Nausea, vomiting, diarrhoea, stomatitis, rectal irritation, anorectal pain. Immune system disorders: Hypersensitivity reactions. Investigations: Increased hepatic enzymes and blood bilirubin. Metabolism and nutrition disorders: Electrolyte imbalance. Nervous system disorders: Paraesthesia, confusion, disorientation, nystagmus.
Potentially Fatal: Nephrotoxicity, respiratory depression, neuromuscular blockade.
Drug Interactions
Increased risk of nephrotoxicity with amphotericin B, ciclosporin, capreomycin, vancomycin, teicoplanin, and platinum compounds. Increased risk of ototoxicity with loop diuretics. May impair the absorption of methotrexate, digoxin, phenoxymethylpenicillin and some vitamins. May enhance the therapeutic effect of muscle relaxants. Increased risk of neuromuscular side-effects with general anaesthetics or opioids. May antagonise the effects of neostigmine and pyridostigmine. May increase the hypoglycaemic effect and severity of gastrointestinal side-effects of acarbose. Increased risk of hypocalcaemia with bisphosphonates. May diminish the therapeutic efficacy of oral contraceptives.
CIMS Class
Aminoglycosides
ATC Classification
A01AB08 - neomycin ; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth.
S03AA01 - neomycin ; Belongs to the class of antiinfectives used in ophthalmologic and otologic preparations.
R02AB01 - neomycin ; Belongs to the class of antibiotics used in throat preparations.
J01GB05 - neomycin ; Belongs to the class of other aminoglycosides. Used in the systemic treatment of infections.
A07AA01 - neomycin ; Belongs to the class of antibiotics. Used in the treatment of intestinal infections.
B05CA09 - neomycin ; Belongs to the class of antiinfectives used as irrigating solutions.
D06AX04 - neomycin ; Belongs to the class of other topical antibiotics used in the treatment of dermatological diseases.
S02AA07 - neomycin ; Belongs to the class of antiinfectives used in the treatment of ear infections.
S01AA03 - neomycin ; Belongs to the class of antibiotics. Used in the treatment of eye infections.
Disclaimer: This information is independently developed by CIMS based on neomycin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 CIMS. All rights reserved. Powered by CIMSAsia.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in