Neomycin

May be taken with or without food.

Hypersensitivity to neomycin or other aminoglycosides. Intestinal obstruction, inflammatory or ulcerative gastrointestinal disease, myasthenia gravis. Infants <1 year.

Patient with neuromuscular disorders, Parkinson's disease; hearing impairment; pre-existing vertigo, tinnitus, or hearing loss. Patient with m.1555A>G mitochondrial mutation. Renal and hepatic impairment. Pregnancy and lactation. Monitoring Parameters Monitor serum creatinine/BUN at baseline and periodically during chronic therapy; audiometry in symptomatic patients. Asses for ototoxicity, nephrotoxicity, and neurotoxicity.

Significant: Neurotoxicity; malabsorption with steatorrhoea and diarrhoea, ototoxicity, superinfection (prolonged use). Blood and lymphatic system disorders: Haemolytic anaemia, eosinophilia, Gastrointestinal disorders: Nausea, vomiting, diarrhoea, stomatitis, rectal irritation, anorectal pain. Immune system disorders: Hypersensitivity reactions. Investigations: Increased hepatic enzymes and blood bilirubin. Metabolism and nutrition disorders: Electrolyte imbalance. Nervous system disorders: Paraesthesia, confusion, disorientation, nystagmus.
Potentially Fatal: Nephrotoxicity, respiratory depression, neuromuscular blockade.

Increased risk of nephrotoxicity with amphotericin B, ciclosporin, capreomycin, vancomycin, teicoplanin, and platinum compounds. Increased risk of ototoxicity with loop diuretics. May impair the absorption of methotrexate, digoxin, phenoxymethylpenicillin and some vitamins. May enhance the therapeutic effect of muscle relaxants. Increased risk of neuromuscular side-effects with general anaesthetics or opioids. May antagonise the effects of neostigmine and pyridostigmine. May increase the hypoglycaemic effect and severity of gastrointestinal side-effects of acarbose. Increased risk of hypocalcaemia with bisphosphonates. May diminish the therapeutic efficacy of oral contraceptives.

Aminoglycosides

A01AB08 - neomycin ; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth.
S03AA01 - neomycin ; Belongs to the class of antiinfectives used in ophthalmologic and otologic preparations.
R02AB01 - neomycin ; Belongs to the class of antibiotics used in throat preparations.
J01GB05 - neomycin ; Belongs to the class of other aminoglycosides. Used in the systemic treatment of infections.
A07AA01 - neomycin ; Belongs to the class of antibiotics. Used in the treatment of intestinal infections.
B05CA09 - neomycin ; Belongs to the class of antiinfectives used as irrigating solutions.
D06AX04 - neomycin ; Belongs to the class of other topical antibiotics used in the treatment of dermatological diseases.
S02AA07 - neomycin ; Belongs to the class of antiinfectives used in the treatment of ear infections.
S01AA03 - neomycin ; Belongs to the class of antibiotics. Used in the treatment of eye infections.