Nifedipine


Generic Medicine Info
Administration
Immediate-release: May be taken with or without food. Avoid grapefruit juice.
Retard, GITS & OROS: May be taken with or without food. Avoid grapefruit juice. Swallow whole, do not chew/crush.
Contraindications
Cardiogenic shock, clinically significant aortic stenosis, unstable angina, during or within 1 month of MI, acute attacks of angina; secondary prevention of MI. Concomitant use with rifampicin.
Special Precautions
Patient with hypotension, poor cardiac reserve, heart failure, hypertrophic cardiomyopathy with outflow tract obstruction, diabetes mellitus; undergoing major surgery. Extended-release form: Patient with oesophageal obstruction, Kock pouch (ileostomy after proctocolectomy), inflammatory bowel disease, gastrointestinal strictures (e.g. severe gastrointestinal narrowing, obstruction, bowel resection, gastric bypass, colon cancer, vertical banded gastroplasty). Immediate-release preparations are not recommended to manage angina or hypertension. Avoid abrupt withdrawal. Hepatic impairment. Elderly. Pregnancy and lactation. Patient Counselling This drug may cause dizziness, lethargy, and transient blindness due to severe hypotension; if affected, do not drive or operate machinery. Monitoring Parameters Monitor blood pressure, heart rate, LFTs; signs and symptoms of heart failure and peripheral oedema.
Adverse Reactions
Significant: Peripheral oedema, reflex tachycardia, increased angina or MI, cardiac ischaemic pain, symptomatic hypotension with or without syncope; impaired glucose tolerance. Rarely, bezoar formation (use of extended-release formulation in patients with gastrointestinal strictures). Gastrointestinal disorders: Constipation, abdominal pain, dyspepsia, flatulence, dry mouth, nausea. General disorders and administration site conditions: Feeling unwell, oedema, fatigue. Musculoskeletal and connective tissue disorders: Muscle cramps. Nervous system disorders: Headache, dizziness, tremor. Psychiatric disorders: Nervousness, mood changes. Respiratory, thoracic and mediastinal disorders: Nasal congestion, cough, wheezing, sore throat, dyspnoea. Vascular disorders: Vasodilatation, flushing.
Drug Interactions
May cause additive hypotensive effects with IV Mg sulfate and other antihypertensive agents (e.g. β-blockers, ACE inhibitors, diuretics). Increased exposure and plasma concentration with erythromycin, ritonavir, ketoconazole, fluoxetine, nefazodone, quinupristin/dalfopristin, cisapride, valproic acid, cimetidine, diltiazem. May increase plasma levels of digoxin and tacrolimus. Decreased exposure with phenytoin, carbamazepine, phenobarbital. May reduce plasma concentrations of quinidine.
ATC Classification
C08CA05 - nifedipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
Disclaimer: This information is independently developed by CIMS based on nifedipine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in