Nisoldipine


Generic Medicine Info
Contraindications
Concomitant use w/ CYP3A4 inducers.
Special Precautions
Patients w/ severe aortic stenosis, heart failure, hypertrophic cardiomyopathy (HCM) w/ outflow tract obstruction. Hepatic impairment. Elderly. Pregnancy and lactation. Monitoring Parameters Monitor BP carefully during the initial admin or if there is subsequent upward dose adjustment.
Adverse Reactions
Dizziness, headache, peripheral oedema, chest pain, angina exacerbation, palpitations, vasodilation, pharyngitis, sinusitis, nausea, rash.
Drug Interactions
May increase serum levels w/ CYP3A4 inhibitors. Increased levels w/ cimetidine. Increased antihypertensive effect w/ atenolol. Propranolol attenuated heart rate increase following intake of immediate-release nisoldipine. Reduced bioavailability w/ quinidine. Increased quinidine levels w/ immediate-release nisoldipine.
CIMS Class
Calcium Antagonists
ATC Classification
C08CA07 - nisoldipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
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