Full Generic Medicine Info
Dosage/Direction for Use

Adult: 20 mg daily as a single dose or in 2 divided doses, may be increased to 20 mg bid as necessary to control resistant HTN.
Elderly: Initially, 10 mg daily.
Hepatic impairment: Initially, 5-10 mg once daily.
Should be taken with food.
Unstable angina pectoris, use w/in 1 mth of MI, cardiogenic shock.
Special Precautions
Patients w/ severe aortic stenosis, poor cardiac reserve, heart failure. Hepatic impairment. Elderly. Pregnancy and lactation.
Adverse Reactions
Headache, fatigue, flushing, palpitations, dizziness, peripheral oedema, polyuria, elevated LFTs.
Drug Interactions
Increased serum levels w/ cimetidine. Decreased serum levels w/ bile acids (e.g. ursodeoxycholic acid).
Food Interaction
May increase serum concentration w/ grapefruit juice.
Nitrendipine relaxes coronary vascular smooth muscles by inhibiting Ca ions. It lowers BP primarily by arteriolar dilation.
Absorption: Well absorbed from the GI tract. Absolute bioavailability: 10-30%. Time to peak plasma concentration: 1-3 hr.
Distribution: Plasma protein binding: Approx 98%.
Metabolism: Metabolised in the liver. Undergoes extensive first-pass metabolism.
Excretion: Via urine and faeces (as inactive metabolites, <0.1% as unchanged drug). Terminal elimination half-life: Approx 10-22 hr.
Oral: Protect from light.
CIMS Class
ATC Classification
C08CA08 - nitrendipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
Disclaimer: This information is independently developed by CIMS based on nitrendipine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by
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