Norfloxacin


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult: PO Susceptible infections 400 mg bid. Duration: Uncomplicated UTI caused by susceptible E. coli, Klebsiella pneumoniae, Proteus mirabilis spp: 3 days; uncomplicated UTI caused by other susceptible bacteria: 7-10 days; complicated UTI: 10-21 days; chronic bacterial prostatitis: 28 days. Chronic relapsing UTI 400 mg bid, up to 12 wk, may reduce to once daily if adequate suppression w/in 1st 4 wk.
Administration
Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals, w/ a glass of water. Ensure adequate hydration. Do not take w/ dairy products.
Contraindications
Hypersensitivity to norfloxacin or any other quinolone. Patients w/ known myasthenia gravis, history of tendonitis or tendon rupture associated w/ the use of quinolone.
Special Precautions
Patient w/ known prolongation of QT interval, uncorrected hypokalaemia, known or suspected CNS disorders (e.g. severe cerebral arteriosclerosis) or other factors that predispose to seizures. Kidney, heart or lung transplant recipients. Renal impairment. Pregnancy and lactation. Patient Counselling This drug may cause dizziness and lightheadedness, if affected do not drive or operate machinery. Avoid unnecessary or excessive exposure to sunlight or artificial UV light (e.g. tanning beds, UVA/UVB treatment). If staying outdoors is necessary, use protective measures (e.g. sunscreen, wear loose-fitting clothes). Rest and refrain from exercise as it may increase risk of tendon rupture. Monitoring Parameters Periodically monitor CBC, renal and hepatic function during prolonged therapy.
Adverse Reactions
Dizziness, headache, nausea, abdominal cramping, diarrhoea, vomiting, anorexia, constipation, flatulence, dyspepsia, asthenia, anal/rectal pain, peripheral neuropathy (reversible), tingling of the fingers, hyperhidrosis, arthralgia, arthritis, convulsions, muscle spasms, drug rash w/ eosinophilia and systemic symptoms syndrome (DRESS), leukocytoclastic vasculitis, tendon rupture or tendinitis, photosensitivity/phototoxicity, hepatitis, jaundice, QT interval prolongation, hypoglycaemia. Decreased Hb, WBC, hematocrit and platelet count, increased creatine kinase, urine protein and eosinophils.
Potentially Fatal: Anaphylaxis, Clostridium difficile-associated diarrhoea and colitis, hepatic or acute renal failure.
Drug Interactions
Additive effect on QT interval prolongation w/ class IA (e.g. quinidine) or class III (e.g. amiodarone) antiarrhythmics and other drugs that prolong QT interval (e.g. erythromycin, TCAs, antipsychotic agents). Increased serum concentrations of theophylline. Reduced absorption w/ oral multivitamins and mineral supplements containing divalent or trivalent cations (e.g. Fe, Zn) and antacids containing Al or Mg, sucralfate, buffered didanosine. Prolonged prothrombin time w/ concomitant coumarin anticoagulant. Increased risk of severe tendon disorders w/ corticosteroids. Concurrent use w/ NSAIDs may increase the risk of CNS stimulation and convulsive seizures.
CIMS Class
ATC Classification
J01MA06 - norfloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
S01AE02 - norfloxacin ; Belongs to the class of quinolone antiinfectives. Used in the treatment of eye infections.
Disclaimer: This information is independently developed by CIMS based on norfloxacin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by CIMSAsia.com
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