Olanzapine


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult: PO Schizophrenia Initial: 10 mg/day as a single dose. Adjust dose according to response at intervals of not less than 24 hr to w/in the range of 5-20 mg/day. Acute mixed or manic episodes in bipolar disorder Initial: 10 or 15 mg/day as monotherapy or 10 mg/day as part of combination therapy. Adjust dose in increments or decrements of 5 mg at intervals of not less than 24 hr to a dose of 5-20 mg/day. IM Acute agitation in patients with schizophrenia or mania Initial: 5-10 mg followed by 5-10 mg as required 2 hr later. Max: 20 mg/day (combined oral and parenteral dose). Patients could only receive up to 3 inj in any 24-hr period. Max duration: 3 days, but should transfer to oral therapy as soon as possible.
Administration
May be taken with or without food.
Contraindications
Patient w/ angle-closure glaucoma.
Special Precautions
Patient w/ cerebrovascular disease or conditions predisposing to hypotension, benign prostatic hyperplasia, paralytic ileus, DM, Parkinson's disease, history of blood dyscrasias, bone marrow depression, hypereosinophilic disorders, myeloproliferative disease, history of seizures or conditions that lower the seizure threshold. IM: Acute MI, unstable angina, severe hypotension or bradycardia, sick sinus syndrome, recent heart surgery. Elderly w/ dementia-related psychosis. Hepatic and renal impairment. Pregnancy and lactation. Patient Counselling This drug may cause somnolence and dizziness, if affected, avoid driving and operating machinery. Avoid cigarette smoking. Monitoring Parameters Monitor BP, pulse and resp rate for at least 4 hr after IM inj. Clinical monitoring for hyperglycaemia, plasma lipids and wt.
Adverse Reactions
Somnolence, wt gain, hyperprolactinaemia, increased appetite, dizziness, fatigue, elevated plasma glucose, triglyceride and liver enzyme values, oedema, orthostatic hypotension, constipation, dry mouth; agranulocytosis, eosinophilia, leucopenia, neutropenia, thrombocytopenia; hypertriglyceridaemia, hypercholesterolaemia, bradycardia, arthralgia, sedation.
Potentially Fatal: Neuroleptic malignant syndrome, pancreatitis, stroke, transient ischaemic attack, status epilepticus, exacerbation of pre-existing diabetes sometimes leading to ketoacidosis or coma.
Drug Interactions
Increased olanzapine clearance w/ CYP1A2 inducers (e.g. carbamazepine, omeprazole). Inhibits metabolism w/ CYP1A2 inhibitors (e.g. fluvoxamine). May antagonise effects of levodopa and dopamine agonists. Reduced bioavailability w/ activated charcoal. Additive effect w/ centrally acting drugs or drugs known to increase QT interval.
CIMS Class
ATC Classification
N05AH03 - olanzapine ; Belongs to the class of diazepines, oxazepines and thiazepines antipsychotics
Disclaimer: This information is independently developed by CIMS based on olanzapine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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