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Administration
May be taken with or without food. May be taken w/ meals if GI upset occurs.
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Contraindications
Glaucoma, gastrointestinal obstruction (e.g. pyloric or duodenal obstruction), stenosing peptic ulcer, megaesophagus, prostatic hypertrophy, bladder neck obstruction, myasthenia gravis; tardive dyskinesia (orphenadrine hydrochloride).
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Special Precautions
Patient with CV disease (e.g. heart failure, cardiac decompensation, coronary insufficiency, tachycardia, cardiac arrhythmias), thyrotoxicosis, hypertension, history of drug abuse or acute alcoholism, porphyria, micturition difficulties. Avoid abrupt withdrawal. Some products or formulations are not interchangeable; refer to specific product guideline for further information. Renal and hepatic impairment. Elderly. Pregnancy and lactation. Patient Counselling This drug may cause blurred vision, dizziness or slight euphoria, if affected, do not drive or operate machinery. Monitoring Parameters If for prolonged use, monitor blood, urine, and LFTs.
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Adverse Reactions
Significant: CNS depression, euphoria (increased risk for drug abuse and dependence).
Blood and lymphatic system disorders: Very rarely, aplastic anaemia.
Cardiac disorders: Palpitation, tachycardia.
Eye disorders: Disturbance of visual accommodation.
Gastrointestinal disorders: Dry mouth, gastrointestinal disturbances, nausea, constipation.
Immune system disorders: Hypersensitivity reaction. Rarely, anaphylaxis (IM).
Nervous system disorders: Dizziness, drowsiness, restlessness.
Psychiatric disorders: Confusion, hallucination.
Renal and urinary disorders: Micturition difficulties.
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Drug Interactions
May enhance the sedative effect with other sedatives. May cause anxiety, confusion, tremors with propoxyphene. May increase the antimuscarinic effects with antihistamines, antispasmodics, TCAs, phenothiazines, dopaminergic antiparkinsonian drugs (e.g. amantadine), antiarrhythmics (e.g. disopyramide). Enhanced effect with anticholinergic drugs.
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CIMS Class
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