Concise Prescribing Info
Listed in Dosage.
Dosage/Direction for Use
Adult: PO Muscle spasms As orphenadrine citrate: 100 mg twice daily. Parkinsonism As orphenadrine HCl: Initial: 150 mg daily in divided doses, increased by 50 mg every 2-3 days according to response. Usual maintenance dose: 150-300 mg daily. Max: 400 mg daily in divided doses. IV/IM Muscle spasms As orphenadrine citrate: 60 mg every 12 hr by IM or slow IV inj.
May be taken with or without food. May be taken w/ meals if GI upset occurs.
Prostatic hypertrophy, tardive dyskinesia, porphyria, urinary retention, paralytic ileus, pyloric stenosis, glaucoma, risk of developing hyperpyrexia, cardiospasm, and myasthenia gravis.
Special Precautions
Patient w/ conditions characterized by tachycardia (e.g heart failure, thyrotoxicosis); cardiac arrhythmias, HTN, cardiac impairment, coronary insufficiency, micturition difficulties, history of drug abuse, acute alcoholism. Avoid abrupt withdrawal. Renal and hepatic impairment. Pregnancy and lactation. Patient Counselling This drug may cause dizziness, drowsiness, slight euphoria or blurred vision, if affected, do not drive or operate machineries.
Adverse Reactions
Significant: CNS depression, tachycardia, euphoria, potential for abuse, increased intraocular pressure, GI obstruction, skeletal muscle pain/spasm. Nervous: Dizziness, drowsiness, restlessness, sedation, confusion, nervousness, hallucinations, convulsions, insomnia, coordination disturbances, light-headedness, headache, agitation, tremor, weakness. CV: Palpitation. GI: Dry mouth, nausea, vomiting, GI disturbances, constipation, gastric irritation. Resp: Nasal congestion. Genitourinary: Urinary retention/hesitancy. Ophthalmologic: Accommodation disorders, blurred vision, nystagmus, dilatation of pupils. Dermatologic: Pruritus, urticaria.
Drug Interactions
Increased anti-muscarinic effects (e.g. risk of severe constipation, ileus, atropine-like psychoses and heat stroke) w/ anticholinergic drugs, antihistamines, antispasmodics, tricyclic antidepressants, phenothiazines, dopaminergic anti-parkinsonian drugs (e.g. amantadine) and anti-arrhythmics (e.g. disopyramide). May cause confusion, anxiety and tremors w/ propoxyphene. May cause skeletal muscle spasms/pain w/ analgesics.
Disclaimer: This information is independently developed by CIMS based on orphenadrine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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