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Indications/Uses
Listed in Dosage.
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Dosage/Direction for Use
Adult: PO Muscle spasms As orphenadrine citrate: 100 mg twice daily. Parkinsonism As orphenadrine HCl: Initial: 150 mg daily in divided doses, increased by 50 mg every 2-3 days according to response. Usual maintenance dose: 150-300 mg daily. Max: 400 mg daily in divided doses. IV/IM Muscle spasms As orphenadrine citrate: 60 mg every 12 hr by IM or slow IV inj.
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Administration
May be taken with or without food. May be taken w/ meals if GI upset occurs.
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Contraindications
Prostatic hypertrophy, tardive dyskinesia, porphyria, urinary retention, paralytic ileus, pyloric stenosis, glaucoma, risk of developing hyperpyrexia, cardiospasm, and myasthenia gravis.
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Special Precautions
Patient w/ conditions characterized by tachycardia (e.g heart failure, thyrotoxicosis); cardiac arrhythmias, HTN, cardiac impairment, coronary insufficiency, micturition difficulties, history of drug abuse, acute alcoholism. Avoid abrupt withdrawal. Renal and hepatic impairment. Pregnancy and lactation. Patient Counselling This drug may cause dizziness, drowsiness, slight euphoria or blurred vision, if affected, do not drive or operate machineries.
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Adverse Reactions
Significant: CNS depression, tachycardia, euphoria, potential for abuse, increased intraocular pressure, GI obstruction, skeletal muscle pain/spasm.
Nervous: Dizziness, drowsiness, restlessness, sedation, confusion, nervousness, hallucinations, convulsions, insomnia, coordination disturbances, light-headedness, headache, agitation, tremor, weakness.
CV: Palpitation.
GI: Dry mouth, nausea, vomiting, GI disturbances, constipation, gastric irritation.
Resp: Nasal congestion.
Genitourinary: Urinary retention/hesitancy.
Ophthalmologic: Accommodation disorders, blurred vision, nystagmus, dilatation of pupils.
Dermatologic: Pruritus, urticaria.
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Drug Interactions
Increased anti-muscarinic effects (e.g. risk of severe constipation, ileus, atropine-like psychoses and heat stroke) w/ anticholinergic drugs, antihistamines, antispasmodics, tricyclic antidepressants, phenothiazines, dopaminergic anti-parkinsonian drugs (e.g. amantadine) and anti-arrhythmics (e.g. disopyramide). May cause confusion, anxiety and tremors w/ propoxyphene. May cause skeletal muscle spasms/pain w/ analgesics.
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CIMS Class
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