Orphenadrine


Full Generic Medicine Info
Dosage/Direction for Use

Oral
Pain and muscular spasms in musculoskeletal disorders
Adult: As orphenadrine citrate: 100 mg bid.
Elderly: Dose reduction may be required.

Oral
Drug-induced extrapyramidal symptoms
Adult: As orphenadrine hydrochloride: Initially, 150 mg daily in divided doses, gradually increase by 50 mg every 2-3 days until maximum benefits is attained. Usual maintenance dose: 150-300 mg daily. Max: 400 mg daily in divided doses.
Elderly: Dose reduction may be required.

Oral
Parkinsonism
Adult: As orphenadrine hydrochloride: Initially, 150 mg daily in divided doses, gradually increase by 50 mg every 2-3 days until maximum benefits is attained. Usual maintenance dose: 150-300 mg daily. Max: 400 mg daily in divided doses.
Elderly: Dose reduction may be required.

Parenteral
Pain and muscular spasms in musculoskeletal disorders
Adult: As orphenadrine citrate: 60 mg 12 hourly via IM or slow IV inj.
Elderly: Dose reduction may be required.
Administration
May be taken with or without food. May be taken w/ meals if GI upset occurs.
Contraindications
Glaucoma, gastrointestinal obstruction (e.g. pyloric or duodenal obstruction), stenosing peptic ulcer, megaesophagus, prostatic hypertrophy, bladder neck obstruction, myasthenia gravis; tardive dyskinesia (orphenadrine hydrochloride).
Special Precautions
Patient with CV disease (e.g. heart failure, cardiac decompensation, coronary insufficiency, tachycardia, cardiac arrhythmias), thyrotoxicosis, hypertension, history of drug abuse or acute alcoholism, porphyria, micturition difficulties. Avoid abrupt withdrawal. Some products or formulations are not interchangeable; refer to specific product guideline for further information. Renal and hepatic impairment. Elderly. Pregnancy and lactation. Patient Counselling This drug may cause blurred vision, dizziness or slight euphoria, if affected, do not drive or operate machinery. Monitoring Parameters If for prolonged use, monitor blood, urine, and LFTs.
Adverse Reactions
Significant: CNS depression, euphoria (increased risk for drug abuse and dependence). Blood and lymphatic system disorders: Very rarely, aplastic anaemia. Cardiac disorders: Palpitation, tachycardia. Eye disorders: Disturbance of visual accommodation. Gastrointestinal disorders: Dry mouth, gastrointestinal disturbances, nausea, constipation. Immune system disorders: Hypersensitivity reaction. Rarely, anaphylaxis (IM). Nervous system disorders: Dizziness, drowsiness, restlessness. Psychiatric disorders: Confusion, hallucination. Renal and urinary disorders: Micturition difficulties.
Overdosage
Symptoms: Nausea, vomiting, flushing, dilated pupils, dry mouth and tongue, hot dry skin, fever, hypertension, sinus tachycardia, ataxia, nystagmus, drowsiness, delirium, agitation and visual hallucinations. Management: Administer activated charcoal or perform gastric lavage within 1 hour of ingestion. Establish patent airway and provide oxygen or ventilation to correct hypoxia or hypercapnia; administer intravascular volume expander of dopamine for hypo- or hyperthermia, hypotension; treat skin blisters as burns; administer diazepam for convulsions or delirium. Administer Na bicarbonate (even in the absence of acidosis) and correct hypoxia for cardiac dysrhythmias.
Drug Interactions
May enhance the sedative effect with other sedatives. May cause anxiety, confusion, tremors with propoxyphene. May increase the antimuscarinic effects with antihistamines, antispasmodics, TCAs, phenothiazines, dopaminergic antiparkinsonian drugs (e.g. amantadine), antiarrhythmics (e.g. disopyramide). Enhanced effect with anticholinergic drugs.
Food Interaction
Alcohol may potentiate the CNS depressant effect of this drug.
Action
Orphenadrine, a tertiary amine antimuscarinic, is an indirect skeletal muscle relaxant that is believed to work by central atropine-like effects. Additionally, it has weak antihistaminic and local anaesthetic properties.
Onset: 2-4 hours (oral).
Duration: 4-6 hours.
Absorption: Readily absorbed from the gastrointestinal tract and after an IM inj.
Distribution: Rapidly distributed to tissues. Plasma protein binding: 20%
Metabolism: Extensively metabolised in the liver into approx 8 metabolites.
Excretion: Mainly via urine (8% as unchanged drug). Elimination half-life: 14-16 hours.
Storage
Oral: Store below 30°C. Protect from light, moisture, and heat. Parenteral: Store below 30°C. Protect from light, moisture, and heat.
CIMS Class
Antiparkinsonian Drugs / Muscle Relaxants
Disclaimer: This information is independently developed by CIMS based on orphenadrine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 CIMS. All rights reserved. Powered by CIMSAsia.com
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