Oxolinic acid


Full Prescribing Info
Dosage/Direction for Use

Oral
Urinary tract infections
Adult: 750 mg every 12 hr.
Contraindications
Hypersensitivity. Severe renal impairment. Pregnancy and lactation. G6PD deficiency. Children. Convulsive conditions.
Special Precautions
Impaired renal or hepatic function; exposure to strong sunlight. Elderly.
Adverse Reactions
Urinary stones, muscle pain, hypersensivity reactions (e.g. rash, urticaria, pruritus, photosensitivity, leukopenia, eosinophilia), nausea, vomiting, anorexia, epigastric pain, abdominal pain, diarrhoea, metallic taste, increased LFTs, insomnia, anxiety, nervousness, confusion, vertigo, somnolence, headache, peripheral neuropathy, paraesthesia, photophobia, blurred vision, disturbances in accommodation, diplopia, convulsions, hallucination.
Action
Oxolinic acid is a quinolone antibacterial agent with properties similar to nalidixic acid. It interferes with bacterial DNA replication probably by inactivating bacterial DNA gyrase (type II topoisomerase).
Absorption: Absorbed in the GI tract. Peak plasma concentration in 30-60 min.
Distribution: Protein-binding: 80%.
Metabolism: Hepatic.
Excretion: Via urine. Half-life: 4-6 hr.
CIMS Class
ATC Classification
J01MB05 - oxolinic acid ; Belongs to the class of other quinolones. Used in the systemic treatment of infections.
Disclaimer: This information is independently developed by CIMS based on oxolinic acid from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by CIMSAsia.com
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