Oxybutynin


Full Prescribing Info
Dosage/Direction for Use

Oral
Overactive bladder
Adult: 2.5-5 mg bid-tid. May be increased to max 5 mg 4 times daily if necessary. As extended-release preparation: Initially, 5 mg once daily increased by 5 mg every wk if necessary to max 30 mg daily.
Child: >7 yr for nocturnal enuresis: 2.5-3 mg bid increased if necessary to 5 mg bid-tid. Last dose should be given before bedtime. As extended-release preparation: 5 mg once daily, increased by 5 mg wkly if necessary to max 20 mg daily.
Elderly: Initially, 2.5-3 mg bid increased to 5 mg bid if necessary.

Oral

Neurogenic bladder disorders
Child: >5 years As immediate-release tab: 5 mg bid up to tid. As extended-release tab: 5 mg once daily. May increased to Max 15 mg once daily in 5 mg daily increments.

Transdermal
Overactive bladder
Adult: 1 transdermal system (delivering 3.9 mg per day) applied to dry, intact skin on the abdomen, hip, or buttock twice wkly.
Administration
May be taken with or without food.
Contraindications
GI obstruction or atrophy, severe toxic megacolon, significant bladder outflow obstruction, glaucoma, urinary retention.
Special Precautions
Elderly; hepatic or renal impairment; neuropathy; hyperthyroidism; prostatic hyperplasia; hiatus hernia; cardiac disease, reflux oesophagitis, ulcerative colitis, myasthenia gravis; pregnancy and lactation. High environmental temperature might cause heat prostration (fever with heat stroke due to decreased sweating).
Adverse Reactions
Dry mouth, constipation, nausea, abdominal pain; blurred vision; headache, dizziness, drowsiness; dry skin, rash; photosensitivity, diarrhoea, insomnia, palpitation, weakness, dry eyes, confusion, hypertension, UTI, dyspepsia.
Overdosage
Anticholinergic effects including CNS excitation (e.g. restlessness, tremor, irritability, convulsions, delirium, hallucinations), flushing, fever, dehydration, cardiac arrhythmia, vomiting, and urinary retention may occur after overdose. Treatment should be symptomatic and supportive. Activated charcoal may be administered.
Drug Interactions
Co-administration with other anticholinergic drugs may cause undesirable increased anticholinergic effects. Additive sedation with CNS depressants and alcohol. Concentration may be increased by CYP3A4 inhibitirs (e.g. imidazole antifungals, macrolide antibiotics).
Action
Oxybutynin exerts direct antispasmodic effect on the smooth muscle by inhibiting the muscarinic action of acetylcholine. It exhibits moderate anticholinergic effect, but has potent antispasmodic effects on urinary smooth muscle.
Absorption: Peak plasma concentrations after 1 hr.
Distribution: Crosses the blood-brain barrier; enters breast milk.
Metabolism: Hepatic: Undergoes first-pass metabolism.
Excretion: Excreted in urine and faeces as metabolites. Elimination half life 2-3 hr.
Storage
Oral: Store at 15-30°C (59-86°F). Transdermal: Store at 15-30°C (59-86°F).
ATC Classification
G04BD04 - oxybutynin ; Belongs to the class of urinary antispasmodics.
Disclaimer: This information is independently developed by CIMS based on oxybutynin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by CIMSAsia.com
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