Generic Medicine Info
Nasal: Acute coronary disease, cardiac asthma, angle-closure glaucoma, rhinitis sicca, inflammation or lesions of the skin around the nostrils or nasal mucosa, phaeochromocytoma, trans-sphenoidal hypophysectomy or nasal surgery exposing the dura mater. Concomitant use or within 2 weeks after stopping treatment with MAOIs.
Special Precautions
Patient with severe, uncontrolled or unstable CV disease; angina, uncontrolled hypo- or hypertension, orthostatic hypotension, cerebral or coronary insufficiency, thromboangiitis obliterans, Raynaud's phenomenon, scleroderma, Sjogren's syndrome; diabetes mellitus, thyroid disease (e.g. hyperthyroidism), porphyria, prostatic hyperplasia or urinary obstruction, occlusive vascular disease; angle-closure glaucoma (topical). Children. Pregnancy and lactation.
Adverse Reactions
Significant: Exacerbated vascular insufficiency, acute angle-closure glaucoma; local nasal effects (e.g. burning, stinging, sneezing, increased nasal discharge), rhinitis medicamentosa and rebound nasal congestion (frequent or long-term use). Cardiac disorders: Rarely, tachycardia, palpitations. Eye disorders: Rarely, eye irritation, dryness, redness or discomfort. Gastrointestinal disorders: Dry mouth or throat. Rarely, nausea. Injury, poisoning and procedural complications: Application site reactions (e.g. dermatitis, pruritus, erythema, pain). Investigations: Rarely, increased blood pressure. Nervous system disorders: Rarely, headache. Psychiatric disorders: Rarely, insomnia, anxiety. Respiratory, thoracic and mediastinal disorders: Rarely, nasal dryness, discomfort or irritation; epistaxis. Skin and subcutaneous tissue disorders: Worsening inflammatory lesions of rosacea (topical). Vascular disorders: Rarely, reactive hyperaemia.
Drug Interactions
Increased risk of arrhythmias and hypertension with TCAs, appetite suppressants, amphetamine-like psychostimulants. May antagonise the effects of β-blockers and other antihypertensive agents (e.g. methyldopa, bethanidine, debrisoquine, guanethidine). Increased risk of ergotism with ergot alkaloids (e.g. ergotamine, methysergide). May cause additive CV toxicity with antiparkinsonian agents (e.g. bromocriptine). Increased risk of dysrhythmias with cardiac glycosides.
CIMS Class
Nasal Decongestants & Other Nasal Preparations / Other Dermatologicals
ATC Classification
S01GA04 - oxymetazoline ; Belongs to the class of sympathomimetics used as ophthalmologic decongestants.
R01AB07 - oxymetazoline ; Belongs to the class of topical sympathomimetic combination preparations, excluding corticosteroids. Used as nasal decongestants.
R01AA05 - oxymetazoline ; Belongs to the class of topical sympathomimetic agents used as nasal decongestants.
Disclaimer: This information is independently developed by CIMS based on oxymetazoline from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 CIMS. All rights reserved. Powered by CIMSAsia.com
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