Oxytocin + ergometrine

Generic Medicine Info
Labour induction, 1st or 2nd stage of labour prior to the delivery of anterior shoulder, primary or secondary uterine inertia, severe cardiac disease, severe hypertension, pre-eclampsia, eclampsia, occlusive vascular disease, sepsis. Severe renal and hepatic impairment. Pregnancy.
Special Precautions
Women with mild to moderate hypertension, CV disease (e.g. coronary artery disease), long QT syndrome, Raynaud's phenomenon. Mild to moderate renal and hepatic impairment. In cases of breech and other abnormal presentations, this medicine should not be given until after delivery of the child or in multiple births until the last child has been delivered.
Adverse Reactions
Significant: Angina, myocardial ischaemia, MI, anaphylaxis. Cardiac disorders: Chest pain, bradycardia, arrhythmia. Gastrointestinal disorders: Nausea, vomiting, abdominal pain. Immune system disorders: Angioedema. Nervous system disorders: Dizziness, headache, cerebrovascular accident. Respiratory, thoracic and mediastinal disorders: Dyspnoea. Skin and subcutaneous tissue disorders: Rash. Vascular disorders: Hypertension, hypotension.
Drug Interactions
Increased vasopressor action of vasoconstrictors and sympathomimetics. Enhanced uterine action of prostaglandins and vice versa. Diminished uterotonic effect with inhalation anaesthetics (e.g. halothane, cyclopropane, isoflurane, desflurane, sevoflurane). Oxytocin: Increased risk of arrhythmia with drugs that prolong QT interval. Ergometrine: Reduced therapeutic effect with CYP3A4 inducers. Increased risk of ergot toxicity with CYP3A4 inhibitors (e.g. erythromycin, clarithromycin, ritonavir, indinavir, nelfinavir, delavirdine, ketoconazole, itraconazole, voriconazole, cimetidine). Enhance vasopressor effects of triptans. Potentiated vasoconstrictive action with β-blockers. Diminished therapeutic efficacy of glyceryl trinitrate and other antianginal drugs.
ATC Classification
H01BB02 - oxytocin ; Belongs to the class of oxytocin and analogues. Used in posterior pituitary lobe hormone preparations.
G02AB03 - ergometrine ; Belongs to the class of ergot alkaloids. Used to induce abortion or augment labour and to minimize blood loss from the placental site.
Disclaimer: This information is independently developed by CIMS based on oxytocin + ergometrine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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