Paclitaxel


Generic Medicine Info
Contraindications
Solid tumours in patients with baseline neutrophil counts <1500 cells/mm3. Kaposi sarcoma in patient with baseline neutrophil <1000 cells/mm3 and serious uncontrolled infection. Severe hepatic impairment (as conventional solution). Lactation.
Special Precautions
Patient with pre-existing neuropathies, conduction abnormalities. Hepatic impairment. Elderly. Pregnancy. Premedication with corticosteroid, antihistamine and histamine H2-receptor antagonist may be required to reduce risk of hypersensitivity reaction. Patient counselling This drug may cause mild tiredness and dizziness, if affected, do not drive or operate machinery. Monitoring Parameters Monitor CBC with differential and platelet count; LFT, kidney function; vital signs (frequently during the 1st hour of infusion); cardiac function; infusion site during infusion.
Adverse Reactions
Significant: Bone marrow suppression (e.g. neutropenia); hypotension, hypertension, bradycardia; extravasation, injection site reactions; sensory/peripheral neuropathy, sepsis, nausea, vomiting, diarrhoea. Rarely, conduction abnormalities, CHF, left ventricular dysfunction. Blood and lymphatic system disorders: Anaemia, leukopenia, thrombocytopenia, febrile neutropenia. Cardiac disorders: Tachycardia, arrhythmia, supraventricular tachycardia, chest pain, bradycardia, dyspnoea. Eye disorders: Increased lacrimation, blurred vision. Gastrointestinal disorders: Constipation, stomatitis, abdominal pain and distension. General disorders and administration site conditions: Fatigue, asthenia, pyrexia, malaise, ataxia. Infections and infestations: Candidiasis, conjunctivitis. Injury, poisoning and procedural complications: Injection site reactions (including pain, erythema, localised oedema, induration). Investigations: Increased AST, gamma-glutamyltransferase, blood alkaline phosphatase, serum creatinine; ECG abnormality. Metabolism and nutrition disorders: Anorexia, dehydration, oedema. Musculoskeletal and connective tissue disorders: Arthralgia, myalgia, back pain. Nervous system disorders: Paraesthesia, headache, dizziness, vertigo. Renal and urinary disorders: UTI. Respiratory, thoracic and mediastinal disorders: Upper respiratory tract infection, cough, pulmonary embolism. Skin and subcutaneous tissue disorders: Alopecia, rash, pruritus, erythema, nail discolouration, skin hyperpigmentation, nail changes. Vascular disorders: Flushing, hypertension, hypotension, venous thrombosis.
Potentially Fatal: Anaphylaxis and severe hypersensitivity reactions, pneumonitis.
Drug Interactions
Increased plasma concentration and toxicity with CYP2C8 and CYP3A4 inhibitors (e.g. ketoconazole, erythromycin, fluoxetine, clopidogrel, cimetidine, ritonavir). Decreased plasma concentration and efficacy with CYP2C8 and CYP3A4 inducers (e.g. rifampicin, carbamazepine, phenytoin, efavirenz).
CIMS Class
Cytotoxic Chemotherapy
ATC Classification
L01CD01 - paclitaxel ; Belongs to the class of plant alkaloids and other natural products, taxanes. Used in the treatment of cancer.
Disclaimer: This information is independently developed by CIMS based on paclitaxel from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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