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Indications/Uses
Listed in Dosage.
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Dosage/Direction for Use
Adult: IV Facilitate endotracheal intubation; Muscle relaxant in general anaesth Initial: 50-100 mcg/kg by inj. Maintenance: 10-20 mcg/kg. Facilitate mechanical ventilation in intensive care 60 mcg/kg every 1-1.5 hr or less frequently.
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Special Precautions
Patient w/ burn injury, biliary tract disease, pulmonary disease, muscular dystrophies, myasthenia gravis, myasthenic syndrome, electrolyte disturbance, altered pH, dehydration, CV disease, oedema, raised catecholamine concentration and those at risk of HTN. Renal and hepatic impairment. Childn. Pregnancy and lactation. Patient Counselling Not recommended to drive or operate machinery w/in 24 hr after full recovery from neuromuscular effects. Monitoring Parameters Monitor heart rate, BP, assisted ventilation status.
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Adverse Reactions
Tachycardia, HTN, bradycardia, bronchospasm, hypotension, CV collapse, excessive salivation; pain or local skin reactions at inj site. Rarely, hypersensitivity reactions.
Potentially Fatal: Anaphylaxis. |
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Drug Interactions
Increased effect w/ inhalational anaesth, other non-depolarising muscle relaxants, antibiotics (polypeptide and aminoglycoside group), diazepam, propranolol, thiamine (high dose), MAOIs, quinidine, Mg sulfate, protamine, nitroglycerin, narcotic analgesics, diuretics, phenytoin, α and β adrenergic blockers, imidazoles, norepinephrine and epinephrine and prior suxamethonium. Decreased effect w/ neostigmine, edrophonium, corticosteroids (high dose); KCl, Ca chloride and NaCl; heparin (temporary decrease), azathioprine, theophylline, pyridostigmine, neurolept analgesia and propanidid.
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CIMS Class
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