Paromomycin


Full Prescribing Info
Dosage/Direction for Use

Oral
Intestinal amoebiasis
Adult: 25-35 mg/kg daily in 3 divided doses for 5-10 days.
Child: Same as adult dose.

Oral

Hepatic encephalopathy
Adult: As adjunctive therapy: 4 g daily in divided doses at regular intervals for 5-6 days.
Administration
Should be taken with food. Take during meals.
Contraindications
Hypersensitivity to paromomycin and other aminoglycosides. Intestinal obstruction.
Special Precautions
Patient w/ ulcerative bowel lesions. Prolonged use may result in overgrowth of non-susceptible organisms. Renal impairment. Pregnancy and lactation.
Adverse Reactions
Ototoxicity, anorexia, nausea, vomiting, epigastric burning and pain, increased GI motility, abdominal cramps, diarrhoea, pruritus ani, hypocholesterolaemia, malabsorption of xylose and sucrose, abnormal fat metabolism, headache, vertigo, eosinophilia, exanthema, unexplained haematuria.
Potentially Fatal: Pseudomembranous colitis, nephrotoxicity, neuromuscular blockade.
Action
Paromomycin acts directly on amoeba. It has antibacterial activity against normal and pathogenic organisms in the GI tract and interferes w/ bacterial protein synthesis by binding to 30S ribosomal subunits.
Absorption: Poorly absorbed from the GI tract.
Excretion: Via faeces (approx 100% of the dose, as unchanged drug); via urine (approx 0.1%).
Storage
Oral: Store between 15-30°C. Protect from moisture.
ATC Classification
A07AA06 - paromomycin ; Belongs to the class of antibiotics. Used in the treatment of intestinal infections.
Disclaimer: This information is independently developed by CIMS based on paromomycin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by CIMSAsia.com
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