Pemoline


Generic Medicine Info
Contraindications
Liver impairment; children <6 yr; Tourette's syndrome; psychosis.
Special Precautions
Should only be started in patients with normal baseline LFTs; monitor LFTs every 2 wk. Discontinue if serum alanine aminotransferase is increased, if signs of liver failure develop or if no substantial clinical response within 3 wk of completing dose titration. Renal dysfunction, psychosis, bipolar disorder, DM, cardiovascular disease, seizure disorders, insomnia, porphyria, or hypertension. Potential for drug dependency. Avoid abrupt withdrawal in chronic patients. May impair ability to drive or operate machinery. Pregnancy and lactation.
Adverse Reactions
Insomnia, night terrors, nervousness, restlessness, irritability, euphoria, fatigue and depression; dryness of the mouth, anorexia, abdominal cramps and other GI disturbances; headache, dizziness, tremor, sweating, tachycardia, palpitations, MI, hypertension or hypotension, altered libido, and impotence. Possible growth suppression in children.
Potentially Fatal: Hepatotoxicity.
Drug Interactions
Hypertensive crisis with MAOIs. Reduced seizure threshold in epileptic patients on antiepileptics.
CIMS Class
Other CNS Drugs & Agents for ADHD
ATC Classification
N06BA05 - pemoline ; Belongs to the class of centrally-acting sympathomimetics. Used as CNS stimulant.
Disclaimer: This information is independently developed by CIMS based on pemoline from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in