Pentosan polysulfate sodium


Generic Medicine Info
Administration
Should be taken on an empty stomach. Take at least 1 hr before or 2 hr after meals.
Special Precautions
Patient w/ signs/symptoms of coagulopathy, bleeding disorder (e.g. haemophilia, thrombocytopenia), aneurysm, GI disease (e.g. GI ulcerations, diverticula, polyps), heparin-induced thrombocytopenia; to undergo invasive procedures. Hepatic impairment. Pregnancy and lactation. Monitoring Parameters Monitor CBC, aPTT, prothrombin time, serum Ca, LFT, renal function tests.
Adverse Reactions
Significant: Rectal haemorrhage, bleeding complications (e.g. ecchymosis, epistaxis, gum haemorrhage), alopecia; abnormal LFT. Nervous: Headache, dizziness, insomnia, depression, hyperkinesia. GI: Diarrhoea, nausea, abdominal pain, dyspepsia, vomiting, mouth ulcer, colitis, esophagitis, flatulence, constipation, anorexia. Resp: Pharyngitis, rhinitis, dyspnoea. Dermatologic: Skin rash, pruritus, urticaria.
Drug Interactions
Increased risk of bleeding w/ oral anticoagulants, heparin, NSAIDs, streptokinase, tissue plasminogen activator.
ATC Classification
G04BX15 - pentosan polysulfate sodium ; Belongs to the class of other urologicals.
C05BA04 - pentosan polysulfate sodium ; Belongs to the class of heparins or heparinoids used topically in antivaricose therapy.
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