Phenobarbital


Generic Medicine Info
Administration
May be taken with or without food.
Contraindications
Severe resp depression, acute intermittent porphyria. Severe renal and hepatic impairment. Intra-arterial and SC admin.
Special Precautions
Patient w/ history or sedative/hypnotic addiction; resp disease, depression or suicidal tendencies, hypoadrenalism. Avoid abrupt withdrawal. Mild to moderate renal and hepatic impairment. Elderly or debilitated patient, childn. Pregnancy and lactation. Patient Counselling May impair ability to drive or operate machinery. Monitoring Parameters Monitor CBC, LFTs, mental status and seizure activity.
Adverse Reactions
Bradycardia, syncope, hypotension; anxiety, agitation, ataxia, CNS excitation or depression, confusion, dizziness, drowsiness, hallucinations, hangover effect, headache, hyperkinesias; constipation, nausea, vomiting; agranulocytosis, thrombocytopenia, megaloblastic anaemia; oliguria; pain at inj site, thrombophlebitis (w/ IV use); laryngospasm, resp depression, apnoea (esp w/ rapid IV use), hypoventilation; gangrene (w/ unintentional intra-arterial inj).
Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis.
Drug Interactions
May reduce plasma levels of oral anticoagulants (e.g. warfarin, dicoumarol, acenocoumarol, phenprocoumon), corticosteroids, griseofulvin, doxycycline, Na valproate and valproic acid. May increase CNS depressant effect w/ phenytoin, antihistamines, sedative/hypnotics, tranquilisers. May prolong the effect w/ MAOIs. May reduce the effect of estradiol, progesterone, estrone and other steroidal hormones.
ATC Classification
N03AA02 - phenobarbital ; Belongs to the class of barbiturates and derivatives antiepileptics.
Disclaimer: This information is independently developed by CIMS based on phenobarbital from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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