Phenol


Full Generic Medicine Info
Dosage/Direction for Use

Oral
Pain, oropharyngeal
Adult: For the temporary relief of minor mouth irritation, sore mouth or throat pain, and canker sore pain: As 29 mg loz: Dissolve up to 2 loz slowly in the mouth every 2 hours as necessary. Check with the doctor if symptoms last for >7 days, or if irritation, pain, and redness continue or worsen.
Child: For the temporary relief of minor mouth irritation, sore mouth or throat pain, and canker sore pain: As 29 mg loz: 6-<12 years Dissolve 1 loz slowly in the mouth every 2 hours as needed. Max of 10 loz in 24 hours; ≥12 years Same as adult dose.

Injection
Sclerotherapy of haemorrhoids
Adult: For symptomatic treatment of internal haemorrhoids: As oily phenol 5% inj: Inject 2-3 mL into the submucosal layer at the base of the haemorrhoid. Alternatively, 2-5 mL into the submucosal space of the haemorrhoid or into the apex of the haemorrhoid. Sseveral inj may be given at different sites. Max: 10 mL at any one treatment session.
Child: Contraindicated.
Incompatibility: Incompatible with alkaline salts and non-ionic surfactants.

Mouth/Throat
Pain, oropharyngeal
Adult: For the temporary relief of minor mouth irritation, sore mouth or throat pain, and canker sore pain: As 1.4% spray: 1 spray to the affected area, allow to remain for at least 15 seconds then expectorate. May repeat every 2 hours as needed. As 0.6% oral rinse: Gargle or swish for 15 seconds then spit out; may repeat every 2 hours as necessary. Do not use >12 times daily. Consult the doctor if symptoms do not improve in 7 days, or if irritation, pain, and redness continue or worsen. As phenol 0.175% w/v and halogenated phenols 0.68% w/v aqueous solution: Dilute the solution with 5 parts water, then gargle bid. For common mouth ulcers: May apply the undiluted solution using a clean swab onto affected area(s) tid. Seek medical advice if symptoms persist for >14 days. Dosage recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: For the temporary relief of minor mouth irritation, sore mouth or throat pain, and canker sore pain: As 1.4% spray: ≥3 years Same as adult dose. Use in children <12 years must be supervised. As 0.6% oral rinse: 4 months to <12 years Apply to affected area with a clean swab up to 6 times daily; ≥12 years Same as adult dose. Dosage recommendations may vary among individual products and between countries (refer to specific product guidelines).

Topical/Cutaneous
As an antiseptic agent
Adult: For 1st aid to protect minor scrapes, cuts, or burns from skin infection: As 1.5% paint: Apply a small amount to the affected area 1-3 times daily. As phenol 0.175% w/v and halogenated phenols 0.68% w/v aqueous solution: Dilute the solution with an equal quantity of water, then apply. May be used undiluted in emergencies.
Contraindications
Hypersensitivity. Throat spray: Epiglottitis. Submucosal inj: Use over large areas. Neonates and children.
Special Precautions
Submucosal inj: Select the inj site carefully; not to be given via IV, IM or intrathecal route. Children. Pregnancy and lactation. Patient Counselling Spray/rinse/solution: Do not swallow. As 1.4% spray, 0.6% oral rinse, 29 mg loz: Immediately consult the doctor if the sore throat is severe, persists for >2 days and accompanied or followed by fever, headache, rash, nausea, or vomiting. Topical: Avoid contact with eyes. Do not apply to large areas of the body, deep puncture wounds, animal bites or serious burns. Do not bandage the affected area. As 0.15% paint: Do not use for >7 days unless directed by the doctor. May cause staining of the skin and clothing.
Adverse Reactions
Significant: Submucosal inj: Local ulceration or abscesses, increased systemic absorption and risk of toxic effect (if used over large areas). Rarely, pyrexia, dysuria, transient incontinence, impotence, and prostatic abscess (due to misplaced inj). General disorders and administration site conditions: Inj site pain and discomfort, irritation, ulcer, tissue necrosis (submucosal inj). Hepatobiliary disorders: Hepatitis (submucosal inj). Immune system disorders: Hypersensitivity. Nervous system disorders: Dizziness (submucosal inj). Skin and subcutaneous tissue disorders: Skin irritation, pain, blanching or corrosion (topical).
Potentially Fatal: Submucosal inj: Necrotising fascitis, retroperitoneal sepsis (rare). Throat spray: Rarely, acute epiglottitis, oedema of the epiglottis and/or larynx.
Lab Interference
Submucosal inj: Absorbed phenol may interfere with ferric chloride test for urinary ketones or salicylates, test for ionised serum Ca, serum sulfonamide measurement, Benedict's test for glycosuria and estimation of plasma epinephrine and norepinephrine by trihydroxyindole method.
Action
Phenol is an antiseptic and disinfectant. It has also been used as a local anaesthetic and sclerosing agent. When used in haemorrhoids as a sclerosing agent, it causes fixation of the mucosa of the underlying muscles by producing submucosal fibrosis.
Absorption: Readily absorbed from the gastrointestinal tract, and through intact skin and mucous membranes.
Metabolism: Metabolised in the liver into phenylglucuronide and phenyl sulfate; oxidised to catechol and quinol prior to further conjugation (small amounts).
Excretion: Via urine (as metabolites).
Storage
Injection: Store below 30°C. Protect from light. Mouth/Throat: Store between 20-25°C. Oral: Store below 30°C. Protect from humidity. Topical/Cutaneous: Store between 20-25°C.
CIMS Class
Anorectal Preparations / Mouth/Throat Preparations / Skin Antiseptics & Disinfectants
ATC Classification
C05BB05 - phenol ; Belongs to the class of sclerosing agent used as local injection in antivaricose therapy.
N01BX03 - phenol ; Belongs to the class of other agents used as local anesthetics.
D08AE03 - phenol ; Belongs to the class of phenol and derivatives antiseptics. Used in the treatment of dermatological diseases.
R02AA19 - phenol ; Belongs to the class of antiseptics used in throat preparations.
Disclaimer: This information is independently developed by CIMS based on phenol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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