Povidone iodine


Full Prescribing Info
Dosage/Direction for Use

Mouth/Throat
Oral hygiene
Adult: As 1% solution: Rinse or gargle 10 mL undiluted solution with an equal volume of warm water for 30 seconds 4 times daily for up to 14 days, or as directed.
Child: As 1% solution: >6 years
Same as adult dose.

Mouth/Throat
Mouth and throat infections
Adult: As 1% solution: Rinse or gargle 10 mL undiluted solution with an equal volume of warm water for 30 seconds 4 times daily for up to 14 days, or as directed.
Child: As 1% solution: >6 years
Same as adult dose.

Ophthalmic
Prophylaxis of ocular infection following surgical procedures
Adult: As 5% solution: Instill 2-3 drops onto affected eye(s), leave for 2 minutes then rinse off with 0.9% Na chloride solution.

Topical/Cutaneous

As an antiseptic agent
Adult: As 5-10% solution, 10% gel, 10% ointment, or 10 % aerosol spray: Apply as directed.
Child: As 5-10% solution, 10% gel or 10% ointment: Same as adult dose. As 10% aerosol spray: ≥2 years
Same as adult dose.
Incompatibility: May cause bubbly brown explosion with hydrogen peroxide solution.

Topical/Cutaneous
Acne vulgaris

Adult: As 4% solution: Apply bid directly or with moistened sponge unto affected area, leave for 3-5 minutes then rinse off with water.
Child: As 4% solution: >2 years
Same as adult dose.
Incompatibility: May cause bubbly brown explosion with hydrogen peroxide solution.

Vaginal
Vaginal irritation

Adult: As 0.3% douche: Insert 0.3% solution once daily for 5-7 days.

Topical/Cutaneous
Pyoderma
Adult: As 4% shampoo: Apply 2-3 capfuls in wet scalp, rinse and repeat application, lather with a warm water. Repeat procedure once weekly until desired improvement achieved.
Child: As 4% shampoo: 2-12 years
Apply 1-2 capfuls in wet scalp, rinse and repeat application, lather with a warm water. Repeat procedure once weekly until desired improvement achieved. >12 years Same as adult dose.
Incompatibility: May cause bubbly brown explosion with hydrogen peroxide solution.

Topical/Cutaneous
Seborrhoeic dermatitis
Adult: As 4% shampoo: Apply 2-3 capfuls in wet scalp, rinse and repeat application, lather with a warm water. Repeat procedure once weekly until desired improvement achieved.
Child: As 4% shampoo: 2-12 years
Apply 1-2 capfuls in wet scalp, rinse and repeat application, lather with a warm water. Repeat procedure once weekly until desired improvement achieved. >12 years Same as adult dose.
Incompatibility: May cause bubbly brown explosion with hydrogen peroxide solution.
Contraindications
History of abnormal thyroid function or goitre (e.g. nodular colloid goitre, endemic goitre, Hashimoto's thyroiditis).
Special Precautions
Patient with serious wounds including burns. Renal impairment. Children. Pregnancy and lactation.
Adverse Reactions
Significant: Hypo- or hyper-thyroidism (long-term). Rarely, hypersensitivity reactions; conjunctival hyperaemia, superficial punctuate keratitis, cytotoxicity (ophth). Dermatologic: Rarely, local irritation, pruritus, rash, oedema, burns.
ROUTE(S) : Ophth / Vag: C
ROUTE(S) : Topical: D
Drug Interactions
May increase risk of thyroid-related reactions with lithium. Risk of formation of caustic compounds with ophthalmic formulations containing Hg-based preservatives.
Lab Interference
May interfere with thyroid function tests. False-positive result with contaminated povidone iodine for the detection of occult blood in stool or blood in urine.
Action
Povidone iodine is an iodophore that has a broad-spectrum germicidal activity against a wide range of bacteria, viruses, fungi, protozoa and spores. It is a complex of polyvinylpyrrolidone (povidone) with iodine. After application, it gradually and continuously delivers iodine to exert its germicidal activity.
Absorption: Absorbed from skin, vaginal mucosa.
Distribution: Crosses the placenta and enters breast milk.
Excretion: Mainly via urine.
Storage
Mouth/Throat: Store below 25°C. Protect from light. Ophthalmic: Store below 25°C. Protect from light. Topical/Cutaneous: Store below 25°C. Protect from light. Vaginal: Store below 25°C. Protect from light.
ATC Classification
D09AA09 - povidone-iodine ; Belongs to the class of ointment dressings with antiinfectives.
R02AA15 - povidone-iodine ; Belongs to the class of antiseptics used in throat preparations.
S01AX18 - povidone-iodine ; Belongs to the class of other antiinfectives. Used in the treatment of eye infections.
D11AC06 - povidone-iodine ; Belongs to the class of medicated shampoos.
D08AG02 - povidone-iodine ; Belongs to the class of iodine product antiseptics. Used in the treatment of dermatological diseases.
G01AX11 - povidone-iodine ; Belongs to the class of other antiinfectives and antiseptics. Used in the treatment of gynecological infections.
Disclaimer: This information is independently developed by CIMS based on povidone iodine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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