Pramipexole


Generic Medicine Info
Administration
May be taken with or without food. May be taken w/ meals to minimise GI side effects such as nausea.
Special Precautions
Psychotic disorder, severe CV disease, augmentation (earlier onset, increase and spread of symptoms). Risk of neuroleptic malignant syndrome w/ abrupt withdrawal. Taper dose at 750 mcg/day for a wk, then reduce by 375 mcg/day thereafter. Renal impairment. Pregnancy and lactation. Patient Counselling Patients should be informed to refrain from activities involving mental alertness and physical coordination after drug intake. Monitoring Parameters Monitor BP, signs and symptoms of fibrosis and orthostatic hypotension, development of impulse control disorder, behavioural changes. Perform periodic skin examinations. Regular ophthalmological testing due to risk of visual disorders.
Adverse Reactions
Dyskinesia, sudden onset of sleep and somnolence, hallucinations, abnormal dreams, insomnia, confusion, headache, nausea, dizziness, vomiting, fatigue, constipation, peripheral oedema, visual impairment, decreased appetite.
Drug Interactions
Antagonism of effects occur w/ concomitant use w/ antipsychotics or methyldopa. Increased plasma concentration w/ cimetidine. Additive sedative effect w/ CNS depressants. May increase orthostatic hypotensive effect w/ MAOI.
CIMS Class
Antiparkinsonian Drugs
ATC Classification
N04BC05 - pramipexole ; Belongs to the class of dopamine agonist. Used in the management of Parkinson's disease.
Disclaimer: This information is independently developed by CIMS based on pramipexole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 CIMS. All rights reserved. Powered by CIMSAsia.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in