Prazosin


Generic Medicine Info
Administration
May be taken with or without food. Starting dose is best taken w/ dinner, at least 2-3 hr before retiring. Maintenance doses may be taken w/ or w/o meals.
Special Precautions
Patient with history of micturition syncope in the treatment of benign prostatic hyperplasia (BPH); CHF due to mechanical obstruction (e.g. aortic valve stenosis, mitral valve stenosis, pulmonary embolism, restrictive pericardial disease). Renal and hepatic impairment. Elderly. Pregnancy and lactation. Patient Counselling This drug may cause dizziness and drowsiness, if affected, do not drive or operate machinery. Monitoring Parameters Monitor blood pressure.
Adverse Reactions
Significant: Angina, CNS depression, floppy iris syndrome, orthostatic hypotension, syncope, loss of consciousness, priapism. Cardiac disorders: Dyspnoea, palpitations, tachycardia. Ear and labyrinth disorders: Tinnitus. Eye disorders: Reddened sclera, blurred vision, eye pain. Gastrointestinal disorders: Vomiting, diarrhoea, constipation, dry mouth, abdominal pain. General disorders and administration site conditions: Asthenia. Metabolism and nutrition disorders: Oedema. Nervous system disorders: Paraesthesia, vertigo. Psychiatric disorders: Insomnia, depression, nervousness. Respiratory, thoracic and mediastinal disorders: Nasal congestion. Skin and subcutaneous tissue disorders: Rash. Vascular disorders: Epistaxis, flushing, vasculitis.
Drug Interactions
Additive hypotensive effect with diuretic or other antihypertensive agent (e.g. β-adrenergic blockers). May cause symptomatic hypotension with phosphodiesterase type 5 (PDE5) inhibitors (e.g. sildenafil).
CIMS Class
Other Antihypertensives
ATC Classification
C02CA01 - prazosin ; Belongs to the class of alpha-adrenoreceptor antagonists, peripherally-acting antiadrenergic agents. Used in the treatment of hypertension.
Disclaimer: This information is independently developed by CIMS based on prazosin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 CIMS. All rights reserved. Powered by CIMSAsia.com
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