Pregabalin

May be taken with or without food.

Patients with CV disease (including heart failure), diabetes, history of angioedema episodes or substance abuse. Elderly. Renal impairment. Pregnancy and lactation. Patient Counselling This drug may cause dizziness and somnolence, if affected, do not drive or operate machinery. Monitoring Parameters Monitor for signs of suicidal ideation and behaviour.

Significant: Hypersensitivity, peripheral oedema, dizziness, somnolence, visual disturbance, suicidal ideation, reduced platelet count, rhabdomyolysis, creatinine kinase elevations, weight gain, PR prolongation. Blood and lymphatic system disorders: Neutropenia. Cardiac disorders: Tachycardia, atrioventricular block first degree, sinus bradycardia, CHF. Ear and labyrinth disorders: Vertigo, hyperacusis. Eye disorders: Blurred vision, diplopia, peripheral vision loss, eye swelling, visual field defect, visual acuity reduced, eye pain, asthenopia, photopsia, dry eye, lacrimation increased, eye irritation. Gastrointestinal disorders: Nausea, vomiting, constipation, diarrhoea, flatulence, abdominal distention, dry mouth, GERD, salivary hypersecretion, hypoaesthesia oral. General disorders and administration site conditions: Oedema, abnormal gait, fatigue, pyrexia, thirst, chills, asthenia. Hepatobiliary disorders: Elevated liver enzymes. Metabolism and nutrition disorders: Appetite increased, anorexia, hypoglycaemia. Musculoskeletal and connective tissue disorders: Muscle cramp, arthralgia, back pain, pain in limb, cervical spasm, joint swelling, myalgia, muscle twitching, neck pain, muscle stiffness. Nervous system disorders: Headache, ataxia, abnormal coordination, tremor, dysarthria, amnesia, memory impairment, disturbance in attention, paraesthesia, hypoaesthesia, sedation, balance disorder, lethargy. Psychiatric disorders: Euphoric mood, confusion, irritability, disorientation, insomnia, hallucination, panic attack, restlessness, agitation, aggression, mood swings, apathy. Renal and urinary disorders: Urinary incontinence, dysuria. Reproductive system and breast disorders: Erectile dysfunction, sexual dysfunction, delayed ejaculation, dysmenorrhoea, breast pain. Respiratory, thoracic and mediastinal disorders: Nasopharyngitis, dyspnoea, epistaxis, cough, nasal congestion, rhinitis, snoring, nasal dryness. Skin and subcutaneous tissue disorders: Rash papular, urticaria, hyperhidrosis, pruritus. Vascular disorders: Hypotension, hypertension, flushing, peripheral coldness.
Potentially Fatal: Angioedema.

Additive CNS depressant effects with opiates (e.g. oxycodone) and benzodiazepines (e.g. lorazepam). May increase risk of angioedema with ACE inhibitors.

Anticonvulsants / Anxiolytics / Drugs For Neuropathic Pain

N03AX16 - pregabalin ; Belongs to the class of other antiepileptics.