Primaquine


Generic Medicine Info
Administration
Should be taken with food. Take w/ meals to avoid GI discomfort.
Contraindications
Acutely ill patients suffering from systemic disease manifested by tendency to develop granulocytopenia (e.g. rheumatoid arthritis, lupus erythematosus). Concurrent use w/ other potentially haemolytic drugs or depressants of myeloid elements of the bone marrow. Concomitant admin w/ mepacrine.
Special Precautions
Patient w/ G6PD deficiency, NADH methaemoglobin reductase deficiency. Childn. Pregnancy and lactation. Monitoring Parameters Monitor Hb levels and blood counts routinely.
Adverse Reactions
Abdominal pain, gastric distress, nausea, vomiting; methaemoglobinaemia, haemolytic anaemia (in patients w/ G6PD deficiency), mild anaemia, leucocytosis; HTN, cardiac arrhythmias, prolonged QT interval on ECG, accommodation disturbance. Rarely, leucopenia, agranulocytosis.
Potentially Fatal: Fatal haemolysis in patients w/ G6PD deficiency.
Drug Interactions
Enhanced effect w/ other drugs that prolong the QT interval.
CIMS Class
Antimalarials
ATC Classification
P01BA03 - primaquine ; Belongs to the class of aminoquinoline antimalarials.
Disclaimer: This information is independently developed by CIMS based on primaquine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 CIMS. All rights reserved. Powered by CIMSAsia.com
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