Probenecid


Generic Medicine Info
Administration
Should be taken with food. Take w/ meals or antacids. Ensure adequate fluid intake.
Contraindications
History of uric acid renal calculi or blood disorders; gout patients w/ severe renal impairment. Antibacterial adjunct in patients w/ renal impairment. Childn <2 yr. Concomitant use w/ salicylates.
Special Precautions
Patient w/ history of peptic ulcer. Pregnancy and lactation. Patient Counselling Maintain adequate fluid intake (2-3 L/day). Monitoring Parameters Monitor uric acid, renal function, CBC.
Adverse Reactions
Nausea, vomiting, anorexia, headache, sore gums, flushing, alopecia, dizziness, anaemia, urinary frequency; hypersensitivity reactions w/ fever, dermatitis, pruritus, urticaria; leucopenia, hepatic necrosis, nephrotic syndrome, aplastic anaemia, haemolytic anaemia; precipitation of acute gout.
Potentially Fatal: Severe hypersensitivity reactions (e.g. Stevens-Johnson syndrome) and anaphylaxis.
Drug Interactions
May potentiate methotrexate toxicity. May increase peak plasma concentrations of paracetamol, naproxen, indometacin, ketoprofen, meclofenamate, lorazepam, rifampicin, aciclovir, ganciclovir and zidovudine. May decrease the renal excretion of conjugated sulfonamides. May prolong or enhance the action of oral sulfonylureas thereby increasing the risk of hypoglycaemia. Pyrazinamide may antagonise the uricosuric action of probenecid.
ATC Classification
M04AB01 - probenecid ; Belongs to the class of preparations increasing uric acid excretion. Used in the treatment of gout.
Disclaimer: This information is independently developed by CIMS based on probenecid from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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