Concise Prescribing Info
Listed in Dosage.
Dosage/Direction for Use
Adult: PO Progestogen component of menopausal HRT 200 mg at bedtime for 12-14 days of each mth. Amenorrhoea; Dysfunctional uterine bleeding 400 mg/day for 10 days. IM Amenorrhoea; Dysfunctional uterine bleeding 5-10 mg/day for 5-10 days until 2 days before expected onset of menstruation. Recurrent miscarriage w/ progesterone deficiency 25-100 mg twice wkly from the 15th day of pregnancy until 8-16 wk. May increase to daily inj if needed. Vag Amenorrhoea; Dysfunctional uterine bleeding 45 mg every other day from the 15th-25th day of the cycle. Rectal/Vag Premenstrual syndrome 200 mg/day, up to 400 mg twice daily. Start on days 12-14 of the cycle and continue till onset of menstruation. Intrauterine Contraception As device containing progesterone 38 mg: Insert into the uterine cavity.
Should be taken on an empty stomach (i.e. At least one hour before food or two hours after food).
Hypersensitivity; thrombophloebitis; cerebral apoplexy; severe hepatic impairment; undiagnosed vag bleeding, incomplete abortion, hormone-dependent carcinoma, as a diagnostic test for pregnancy; pregnancy. History or current high risk of arterial disease.
Special Precautions
Discontinue medications if there is sudden partial or complete loss of vision, proptosis or diplopia; migraine and embolic disorders; epilepsy, migraine, asthma, cardiac or renal dysfunction. History of depression, glucose tolerance and diabetic patients. May impair ability to drive or operate machinery. Avoid sudden withdrawal of progesterone; lactation.
Adverse Reactions
GI disturbances, appetite/wt change, fluid retention, oedema, acne, skin rash, urticaria, depression, headache, fever, fatigue, breast changes, hirsutism, changes in libido, altered menstrual cycles or irregular menstrual bleeding (rare).
Drug Interactions
Enhanced clearance with enzyme-inducing drugs eg, carbamazepine, griseofulvin, phenobarbital, phenytoin and rifampicin. Ketoconazole may increase serum levels of progesterone. May inhibit ciclosporin metabolism.
ATC Classification
G03DA04 - progesterone ; Belongs to the class of pregnen (4) derivative progestogens.
Disclaimer: This information is independently developed by CIMS based on progesterone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by
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