Propantheline bromide


Generic Medicine Info
Administration
Should be taken on an empty stomach. Take ½ hr before meals.
Contraindications
Obstructive disease of the gastrointestinal tract (e.g. pyloroduodenal stenosis, paralytic ileus, achalasia); obstructive uropathy (e.g. bladder-neck obstruction due to prostatic hypertrophy), intestinal atony, severe ulcerative colitis, toxic megacolon, hiatal hernia associated with reflux oesophagitis, unstable CV adjustment in acute haemorrhage, myasthenia gravis, glaucoma; tachycardia secondary to cardiac insufficiency or thyrotoxicosis.
Special Precautions
Patient with ulcerative colitis, autonomic neuropathy, hyperthyroidism, CV disease (e.g. coronary artery disease, CHF, hypertension, acute MI) or severe heart disease, pyrexia, GERD, known or suspected gastrointestinal infections, chronic lung disease, Down's syndrome. Patient subjected to hot weather and/or exercise. Avoid use in patients with ileostomy or colostomy. Renal and hepatic impairment. Elderly. Pregnancy and lactation. Patient Counselling This drug may cause drowsiness or blurred vision, if affected, do not drive or operate machinery.
Adverse Reactions
Significant: Drowsiness, blurred vision, diarrhoea, heat prostration (in presence of high environmental temperature), reduced bronchial secretions. Cardiac disorders: Bradycardia followed by tachycardia, palpitations, arrhythmias. Eye disorders: Dilatation of pupils with loss of accommodation and sensitivity to light, increased intraocular pressure. Gastrointestinal disorders: Dryness of the mouth, difficulty in swallowing, constipation, nausea, vomiting, ageusia. General disorders and administration site conditions: Thirst, weakness. Immune system disorders: Hypersensitivity reactions. Nervous system disorders: Dizziness, headache. Psychiatric disorders: Nervousness, insomnia, mental confusion. Renal and urinary disorders: Urinary hesitancy and retention. Reproductive system and breast disorders: Suppression of lactation, impotence. Skin and subcutaneous tissue disorders: Dryness of the skin, decreased sweating. Vascular disorders: Flushing.
Drug Interactions
Delayed gastric emptying caused by propantheline may alter the absorption of other drugs. May increase the serum digoxin levels when used concurrently with slow-dissolving digoxin tab. Enhanced absorption of nitrofurantoin. May reduce and delay the absorption of paracetamol. May reduce the absorption of ketoconazole and levodopa. May result in excessive muscarinic blockade with synthetic and semi-synthetic antimuscarinic agents, belladonna alkaloids, narcotic analgesics (e.g. pethidine), class I antiarrhythmic drugs (e.g. procainamide, quinidine, disopyramide), TCAs, phenothiazines, antihistamines, or other drugs with antimuscarinic activity. May reduce effects of haloperidol and sublingual tab of nitrates. May antagonise the gastrointestinal activity of domperidone, cisapride, metoclopramide. May antagonise the effects of parasympathomimetics. May potentiate sedative effect of phenothiazines. May enhance the ulcerogenic effect of K chloride. May result in increased intraocular pressure with corticosteroids.
CIMS Class
Antispasmodics / Other Drugs Acting on the Genito-Urinary System
Disclaimer: This information is independently developed by CIMS based on propantheline bromide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 CIMS. All rights reserved. Powered by CIMSAsia.com
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