Propranolol + hydrochlorothiazide


Full Generic Medicine Info
Dosage/Direction for Use

Oral
Hypertension
Adult: Propranolol HCl 40mg + Hydrochlorothiazide 25mg (tablets). Start with ½ to 1 tab bid. Increase gradually as required up to max of 4 tabs daily.
Contraindications
Cardiogenic shock, sinus bradycardia & > first-degree block, bronchial asthma, CHF (unless the failure is secondary to tachyarrhythmias treatable with propranolol), anuria patients, hypersensitivity to either component & sulfonamide allergy.
Special Precautions
Avoid abrupt discontinuation of therapy; diabetes mellitus, thyrotoxicosis; renal/hepatic impairment; beta-blockade may interfere with glaucoma screening test. Monitor serum electrolytes periodically; pregnancy & lactation.
Adverse Reactions
Hypotension, intensification of A-V block, bradycardia, paraesthesia, depression, vivid dreams, visual disturbances, fatigue, lethargy, nausea, epigastric distress, constipation, diarrhoea, airway resistance, impotence, alopoecia, agranulocytosis, purpura, fever, photosensitivity, masking of hypoglycaemic symptoms; hyperglycaemia, hyperuricaemia, pancreatitis may occur.
Potentially Fatal: CHF, severe hypotension.
Drug Interactions
Alum hydroxide gel, ethanol reduce propranolol absorption, cimetidine inhibits propranolol hepatic clearance. Propranolol reduces theophylline clearance. Concurrent steroid use may cause hypokalemia.
Potentially Fatal: Exaggerated hypotension with catecholamine depletors & other antihypertensives. NSAIDs blunt antihypertensive effect. Insulin requirements in diabetics may be altered.
Food Interaction
Food may delay absorption of propranolol while it may increase absorption of thiazides; overall, bioavailability is increased.
Lab Interference
A propranolol metabolite may interfere with bilirubin measurements (diazo method) & with determination of metanephrine by pisano method. Prolonged thiazides may interfere with parathyroid function tests interpretation.
Action
Propranolol is a non-selective β-blocker which reduces heart rate, cardiac output and blood pressure. Hydrochlorthiazide increases renal excretion of sodium, chloride and water. There is a secondary loss of K and bicarbonate.
CIMS Class
Beta-Blockers / Diuretics
ATC Classification
C07AA05 - propranolol ; Belongs to the class of non-selective beta-blocking agents. Used in the treatment of cardiovascular diseases.
C03AA03 - hydrochlorothiazide ; Belongs to the class of low-ceiling thiazide diuretics.
Disclaimer: This information is independently developed by CIMS based on propranolol + hydrochlorothiazide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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